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Associate Scientist - Chemistry

citytherapeutics
Cambridge, MA Full Time
POSTED ON 11/12/2025 CLOSED ON 1/12/2026

What are the responsibilities and job description for the Associate Scientist - Chemistry position at citytherapeutics?

We are seeking a dedicated and detail-oriented Associate Scientist to join our Chemistry team in developing next-generation RNA medicines. The ideal candidate will be highly motivated, passionate about early-discovery work, eager to learn, and capable of adapting flexibly to a dynamic work environment.

Please note this is a full-time onsite opportunity

Responsibilities: 

  • Independently performs a variety of moderate to complex QC testing to support internal synthesis, biology, bioanalytical, and CMC activities in an R&D setting. Contributes to the expansion of QC capabilities by contributing to continuous method improvement and implementation of new analytical tests.
  • Demonstrates knowledge of analytical testing (U/HPLC, LC-MS, endotoxin, spectroscopy, etc.) to support method implementation and routine testing.
  • Operate, maintain, and troubleshoot laboratory instrumentation such as Cary UV-Vis, Endosafe nexgen-MCS, osmometer, pH meter, Agilent LC-QTOF, and other state-of-the-art laboratory equipment, ensuring their proper use and performance
  • Closely work with internal research departments to communicate timelines and facilitate QC requests.
  • Track progress, generate status updates, organize experimental data, and present in both written and oral formats at cross-functional team meetings.
  • Prepare SOPs and accurately record detailed experimental procedures and results in electronic lab notebooks. Peer review data related to chemistry testing.

Qualifications:

  • BS in Chemistry or a related field.
  • At least 1-2 years of chemistry lab experience in an industrial or academic setting, preferably in RNA therapeutics.
  • Knowledge of analytical chemistry and/or oligonucleotide chemistry, including purity analysis by LC-MS, analysis of impurities, and characterization of compounds by mass spectrometry etc.

City Therapeutics is accepting resumes/CVs from direct applicants only.  Recruitment Agency inquiries or submissions will not be accepted at this time.

City Therapeutics is an Equal Opportunity and Affirmative Action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.  

Salary.com Estimation for Associate Scientist - Chemistry in Cambridge, MA
$119,464 to $147,736
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