Demo

Principal Mechanical Engineer

CERENE cryotherapy device by Channel Medsystems
Berkeley, CA Full Time
POSTED ON 1/3/2026
AVAILABLE BEFORE 7/1/2026

Principal Mechanical Engineer


Location: Berkeley, CA- Office based


Channel Medsystems is a privately held, commercial-stage company dedicated to transforming women’s healthcare through the development and commercialization of its flagship product, the Cerene® Cryotherapy Device. Cerene provides gynecologists with an innovative solution for treating women suffering from heavy menstrual bleeding (HMB) and dysmenorrhea. The Class 3, FDA-approved procedure requires no capital equipment and can be performed in the convenience of a gynecologist’s office without general anesthesia or operating-room resources. The Company is committed to advancing cryotherapy as a new standard of care to provide women a modern alternative to invasive surgery or long-term medications for the treatment of heavy menstrual bleeding.


This key position on the engineering team requires a high level of responsibility, self-motivation and commitment. The ideal candidate is an experienced mechanical engineer who has successfully implemented complex systems to scale-up production, lower costs, and improve gross margin.


JOB DUTIES AND RESPONSIBILITIES:

  • Manage a multi-year COGS reduction program having Board level visibility
  • Establish in-house manufacturing for a critical subassembly
  • Outsource & qualify high-volume component suppliers
  • Develop supplier capabilities as required
  • Implement design & process changes to further reduce costs
  • Create & manage detailed project plan, balancing competing priorities
  • Bench test & characterize component & subassembly performance
  • Hire and manage consultants with technical expertise
  • Oversee design, construction & installation of high-pressure control system
  • Specify, purchase & qualify other necessary production equipment
  • Define compliance program to meet industry standards
  • Write manufacturing process instructions & train operators
  • Write & execute V&V test protocols and reports
  • Create documentation for DHF, Technical File, and regulatory filings
  • Support regulatory filings & quality audits
  • Lead brainstorming, design review & risk management meetings
  • Contribute to Channel’s IP portfolio


ESSENTIAL REQUIREMENTS:

  • BS or MS degree in mechanical engineering or a related discipline
  • 15 years in medical device or another highly regulated industry
  • Program management of deliverables, timelines, resources, etc.
  • Experience using SolidWorks & other design, analytical & prototyping tools
  • Working knowledge of 21 CFR Part 820 & ISO14971
  • Technical writing & documentation
  • Strong interpersonal & communication skills


Please respond to: careers@cerene.com

  • Resume
  • Salary requirements
  • Recent examples highlighting your experience and qualifications


Agency and Third-Party Recruiter Notice:

Agencies that submit a resume to Channel Medsystems must have a current Agreement executed by the company. In addition, Agencies may only submit candidates to positions for which they have been invited to do so by Channel Medsystems.


Channel Medsystems is an equal opportunity employer and consistent with federal, state, and local requirements. Channel Medsystems will consider requests for reasonable accommodation based on disability or sincerely held religious beliefs where it can do so without undue hardship for the company. Channel Medsystems is proud to be an Equal Opportunity Employer inclusive of disability and veterans.

Salary.com Estimation for Principal Mechanical Engineer in Berkeley, CA
$148,740 to $177,110
If your compensation planning software is too rigid to deploy winning incentive strategies, it’s time to find an adaptable solution. Compensation Planning
Enhance your organization's compensation strategy with salary data sets that HR and team managers can use to pay your staff right. Surveys & Data Sets

What is the career path for a Principal Mechanical Engineer?

Sign up to receive alerts about other jobs on the Principal Mechanical Engineer career path by checking the boxes next to the positions that interest you.
Income Estimation: 
$158,725 - $194,124
Income Estimation: 
$119,658 - $160,028
Income Estimation: 
$197,917 - $247,739
Income Estimation: 
$85,954 - $106,408
Income Estimation: 
$106,299 - $135,354
Income Estimation: 
$108,186 - $133,193
View Core, Job Family, and Industry Job Skills and Competency Data for more than 15,000 Job Titles Skills Library

Job openings at CERENE cryotherapy device by Channel Medsystems

  • CERENE cryotherapy device by Channel Medsystems Berkeley, CA
  • Manufacturing Engineer (New Product Introduction) Location: Berkeley, California – Office based Channel Medsystems is a privately held, commercial-stage co... more
  • 10 Days Ago

  • CERENE cryotherapy device by Channel Medsystems Berkeley, CA
  • Senior Mechanical Engineer Location: Berkeley, CA – Office based Channel Medsystems is a privately held, commercial-stage company dedicated to transforming... more
  • 10 Days Ago

  • CERENE cryotherapy device by Channel Medsystems Berkeley, CA
  • Principal Software Engineer Location: Berkeley CA – Office based Channel Medsystems is a privately held, commercial-stage company dedicated to transforming... more
  • 10 Days Ago


Not the job you're looking for? Here are some other Principal Mechanical Engineer jobs in the Berkeley, CA area that may be a better fit.

  • San Francisco Bay Area Rapid Transit District (BART) Hayward, CA
  • Pay Rate $144,443.00 / annually (MINIMUM) to $218,831.00 / annually (MAXIMUM) - (Non-Represented Pay Band 8) Initial salary is negotiable between $144,443.... more
  • 27 Days Ago

  • Murray Company Mechanical Contractors San Leandro, CA
  • Come grow with us... At Murray Company, how we operate is defined by shared values that are 100 years in the making - Safety, Quality, Honesty, Hard Work a... more
  • 25 Days Ago

AI Assistant is available now!

Feel free to start your new journey!