What are the responsibilities and job description for the Scientist I/II, In Vivo Pharmacology position at Capable Labs?
About the Role
You’ll work closely with the founders and a small team from MIT, Harvard Medical School, Baker Lab, and Radical Numerics.
We are looking for speed and rigor, coupled with excitement and drive. In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy.
Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better. You will be surrounded by people who care intensely about the work, get close feedback from the people making scientific and company-defining decisions, and have room to own increasingly important problems.
We believe excellent work should be met with meaningful reward, ownership, and trust. Responsibility is earned through contribution, not title alone: anyone who demonstrates the judgment, rigor, and follow-through to move important work forward can earn meaningful scope, from junior scientists to senior scientists.
What You’ll Do
Design, run, and interpret mouse studies to evaluate therapeutic candidates across efficacy and safety.
Dose mice using routes including IP, IV, SC, PO, intranasal, and other relevant delivery methods depending on tissue, mechanism, exposure goals, and study design.
Collect blood, plasma, serum, and tissues including liver, kidney, spleen, lung, brain, muscle, heart, tumor, and disease-relevant organs.
Perform surgeries and specialized in vivo procedures as needed, with training from the Capable Labs team where appropriate.
Analyze PK/PD, efficacy, and tolerability data to decide what dose, route, schedule, tissue, timepoint, or candidate to test next.
Who You Are
You do not need to have experience with every route, procedure, or assay listed here.
You have hands-on experience running mouse studies in biotech, pharma, academia, or a closely related setting.
You are comfortable dosing mice by multiple routes, including IP and IV, and ideally have experience with more specialized routes such as intranasal delivery.
You know how to design studies that answer the core translational question: did the drug reach the right tissue, engage the target, move the pathway, improve the phenotype, and remain tolerable?
You are comfortable with in-life execution, necropsy, tissue collection, blood collection, sample tracking, and coordination with downstream molecular, histology, and biomarker assays.
You move quickly without lowering the scientific bar. You can turn the last dataset into the next well-controlled mouse study, with explicit hypotheses, dose rationale, endpoints, controls, and go/no-go criteria.
You do not need to be loud, hyper-social, or performatively enthusiastic to thrive here. Some people do extraordinary work quietly and independently. We value that. Culture at Capable Labs is about trust, clarity, respect, urgency, and exceptional work.
Pay & Benefits
$105,000–$155,000 salary
Equity options with an implied current value of approximately $50,000–$200,000 before exercise cost, taxes, dilution, and liquidity risk
Compensation depends on qualifications, skills, competencies, and experience
Visa sponsorship available (O1 and others)
Wellness budget: $500 per month for training, supplements, personal trainers, and everything you need to become your best self
Comprehensive healthcare coverage with a range of medical options
Application Process
Initial application
First phone screen
Second phone screen, approximately 30 minutes
In-person work trial in San Francisco
The work trial is designed to give both sides a realistic sense of working together and for you to get to know the founding team!
Apply Today
Applying takes 5 minutes and we encourage you to apply as soon as possible. We're evaluating candidates on a rolling basis and want to make an offer quickly.
Compensation Range: $105K - $155K
Salary : $105,000 - $155,000