Director, Chemical Development (Process Chemist)

Who We Are

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Summary

Calico is seeking an experienced and strategic Director of Chemical Development to lead and oversee all aspects of process chemistry and manufacturing for our mid- to late-stage small molecule programs. This role is critical to advancing our pipeline toward commercialization and requires deep technical expertise, leadership, and cross-functional collaboration.

Key Responsibilities

• Lead chemical development strategy for small molecule programs from Phase 2 through commercialization, ensuring robust, scalable, and cost-effective processes
• Provide technical leadership in route selection, process optimization, impurity control, and analytical support in collaboration with internal teams and external partners
• Manage CMC timelines, budgets, and deliverables in alignment with program goals and regulatory requirements
• Oversee technology transfer and scale-up activities at CDMOs, ensuring successful cGMP manufacturing for clinical and commercial supply
• Author and review CMC sections of global regulatory submissions and support regulatory interactions and inspections
• Serve as the technical point of contact with external CMOs and drive performance, quality, and compliance
• Collaborate cross-functionally with Quality, Regulatory, Supply Chain, and Project Management teams to ensure alignment and execution
  
  

Position Requirements

• Ph.D. in Organic Chemistry
• Minimum 15 years of experience in process chemistry, with a strong focus on mid to late-stage small molecule development
• Demonstrated experience in route design, process scale-up, and cGMP manufacturing
• Proven track record in supporting regulatory submissions and health authority interactions
• Solid background in Quality by Design, modern process analytical technology, risk management, and process validation
• Understanding of current regulatory guidances
• Expertise with solid-state chemistry, crystallization, and particle engineering
• Experience managing CDMOs and CROs with a focus on quality, cost, and delivery
• Strong problem-solving, project management, and communication skills
• Ability to lead cross-functional teams and mentor junior staff
• Must be willing to work onsite at least 4 days a week
  
  

The estimated base salary range for this role is $238,000 - $250,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.