Scientist I

Overview

Business Title: Biophysicist

Position Title: Scientist I

Division: Consumer Products Services

Entity: ATL

Location: Louisville, CO

Reports to: Manager

FLSA: Non-Exempt

Hours Worked: Typically, Monday through Friday, forty-hours per week. However, must be flexible to meet the needs of the department and complete other projects as assigned.

Position Summary

The Biophysicist is responsible for contributing to hit-to-lead discovery efforts. The responsibilities of this position include employing multiple technologies to biophysically characterize small molecule-protein, protein-protein, and other complex interactions. This position is an opportunity to learn and grow within a dynamic biophysics team that supports EMD. Our multidisciplinary team combines medicinal chemistry, biophysics, structural biology, chemical biology, cell biology, and enzymology to identify molecular leads that result in targeted therapeutics.

Duties And Responsibilities

It is everyone’s responsibility to live out our Values and Absolutes by Shaping a World of Trust while ensuring responsible progress.

• Characterize protein-ligand and protein-protein interactions using a variety of biophysical methods including but not limited to; SPR, BLI, fluorescence spectroscopy, light scattering techniques, intact protein mass spectrometry, and DSF.
• Biophysically characterize protein samples destined for multiple workflows.
• Use biophysical tools to interrogate protein-ligand and/or protein-protein interactions to triage or advance compound or large molecule series.
• Learn and develop technical expertise in protein biochemical and biophysical characterization across multiple platforms which may lay outside the current skill set.
• Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design.
• Adapt to highly dynamic project priorities, with diligent and rapid communication of scientific results and insights to the team, including maintaining an ELN and uploading data to the database.
• Perform final review and interpret data / reports. Perform critical error review.
• Review and close root cause analysis and corrective actions.
• Works directly with external contacts to implement new testing or process initiatives.
• Assist in the coordination of technical & administrative aspects of various departmental projects, providing direction to techs.
• Perform background/literature research to help further research goals.
• Conduct operational audits to identify defects and inconsistencies.
• Reviews contract requirements prior to testing in order to assure adherence to client requirements, and coordinates testing between labs.
• Perform final review and interpret data / reports for external regulatory agencies.
• Write, implement and update SOPs, test protocols, and technical procedures to facilitate department development and improve quality.
• Method development – write and adapt custom methodology for custom mat
• Comply with clients and Bureau Veritas Consumer Products Services, Inc management systems in accordance with appropriate regulatory agencies.
• Follows the guidelines set forth by clients and the Bureau Veritas Consumer Products Services, Inc Quality Manual and Safety / Chemical Hygiene Plan.
• Adhere to the requirements of the BV-CPS Quality System.
• Other duties as defined by Manager, department needs and workload.
  
  

Skills & Proficiencies

• Experience characterizing protein-protein or protein small molecule interactions with mainstream biophysical techniques.
• Direct experience in large or small molecule assay development for SPR, BLI, DSF, or fluorescence-based techniques.
• Highly organized with excellent analytical, documentation and multi-tasking skills.
• Proven ability to work in a flexible, team-oriented environment.
• Excellent interpersonal skills with the ability to communicate and interact well with colleagues at all levels.
• Working knowledge of chemical labeling methods and technologies.
• Working knowledge of automation technologies (e.g. SPT Labtech, Tecan).
• Working knowledge of fluorescent-based methods or assay development (e.g. FP, FRET, etc.).
• Committed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysical analysis
• Champions Company Values
  
  

Education And Experience

• BS, MS, or PhD in Biochemistry, Chemical Biology, or a related field.
• Minimum of two (2) years’ experience characterizing protein-protein or protein small molecule interactions with mainstream biophysical techniques.
  
  

An equivalent combination of education and experience may be accepted in lieu of above.

Compensation Range: $45.00-$51.00 per hour (e.g., the job posting is not necessarily reflective of actual compensation that may be earned, and actual compensation is subject to variation due to such factors as location, education, experience, and skillset).