Senior Research Scientist, CRISPR screening operations

The Broad Institute's Cancer Dependency Map (DepMap), part of the Cancer Program, aims to comprehensively map cancer vulnerabilities using CRISPR-based functional genomics and other high-throughput screening methods to identify optimal therapeutic targets. DepMap leads the DepMap Consortium, a collaboration with leading pharmaceutical and biotech companies to build this pre-clinical resource, and is a key partner in PedDep, an initiative accelerating target discovery for childhood cancers.

We are seeking an experienced scientist to lead the day-to-day operation of our internal CRISPR screening and profiling platform. This is a production-focused role: you will run and manage large-scale screens as a reliable, high-throughput pipeline - similar to leading a core facility - rather than designing novel experiments.

You'll work closely with experimental scientists, project managers, and data analysts to keep screening data flowing on schedule and at a consistently high standard of quality.

The ideal candidate has hands-on experience running CRISPR screens at scale in a production or core-facility setting, and knows how to keep a pipeline running smoothly: staffing, SOPs, timelines, and quality control.

This role offers the chance to build deep expertise in functional genomics infrastructure within a leading cancer research program, with regular exposure to both academic and industry collaborators.

Key Responsibilities

• Lead daily operations of large-scale CRISPR screens and other high-throughput screening workflows, treating screening as a production pipeline with defined throughput, quality, and turnaround targets.
• Develop and maintain SOPs covering experimental execution, data acquisition, and quality control.
• Manage project timelines, budgets, and resource allocation across concurrent screens.
• Supervise and mentor a team of 2 research associates; coordinate with scientists, project managers, and analysts to keep projects on track.
• Maintain accurate records in the Laboratory Information Management System (LIMS) and ensure data is delivered in a form ready for downstream analysis.
• Continuously improve pipeline efficiency, reproducibility, and scalability as screening volume grows.

Qualifications

• Ph.D. or equivalent experience in Cancer Biology, Molecular Biology, Biochemistry, Genetics, or a related field.
• 3 years running large-scale CRISPR screens or other high-throughput screening methods.
• Experience operating in a production-oriented lab environment (e.g., a core facility, screening center, or similar high-throughput operation).
• Prior experience managing lab personnel.
• Proficiency with LIMS, electronic lab notebooks (ELNs), and project management software.
• Strong organizational skills and comfort managing multiple concurrent projects against fixed timelines.
• Clear communicator, comfortable working across scientific, operational, and data teams.