Postdoctoral Associate - Cardiovascular Disease Initiative (CDI)

The candidate will work on NIH funded as well as exploratory academic projects and will conduct experimental research studies at the bench, supervise a research associate, and contribute to therapeutics project(s) targeting cardiovascular disease.

Example workstreams for projects include: designing high-throughput CRISPR-based screens in hPSC-derived cells, characterizing gene functions in hPSC-derived cells, and validating potential drug targets. Other tasks include developing assays for small molecule drug discovery, generating datasets using single-cell RNA sequencing, and validating gene and protein expression with immunofluorescent techniques and in situ hybridization. Additionally, work may involve creating and validating in vitro and in vivo disease models and conducting experiments to understand target gene functions.

This is an excellent opportunity for a highly motivated candidate interested in exploring the early stages of drug development in a vibrant atmosphere.

REQUIREMENTS

• Ph.D. in Biology (Developmental, Molecular, Cellular Biology), Genetics, Biochemistry, or related life science field with 0-2 years of experience in academic setting
• At least one first author publication in a basic/mechanistic area of biology
• Experience in working with pluripotent stem cells, CRISPR genome editing, single-cell RNA sequencing, cell-based imaging techniques
• Hands-on experience in cellular assay development and proficiency with standard assay formats (e.g. flow cytometry, imaging, luminescence-/fluorescence-based cellular readouts, immunohistochemistry) in primary and cultured cells
• Experience with cardiac electrophysiology is preferred
• Experience with mouse models especially in the cardiovascular field is a plus
• Experience with computational skills is a plus
• Ability to develop research plans for executing strategy, operate and maintain equipment, and perform laboratory work, with complete independence
• Track record of working on complex problems, and ability to integrate data from multiple disciplines
• Strong interpersonal, influencing, and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts
• Outstanding verbal and written communication abilities
• Ability to adapt to and effectively manage changes in a fast paced and dynamic environment
• A passion and curiosity for science and sense of urgency to find new medicines to benefit patients

The successful candidate will be a results-focused, team-oriented, creative, bench scientist, able to excel in a fast-track environment. The candidate must be self-motivated, detail-oriented and exhibit strong problem-solving skills. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with project teams, peers, and management, for identifying and achieving research goals.

The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.

At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.

The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.

Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.