Scientist I – Cell Screening and Pharmacology, Discovery Technology

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

We are growing our DAC research team with a hands-on in vitro screening and pharmacology scientist who will help build and shape the screening and pharmacological characterization capability for Degrader Antibody Conjugates (DACs). Our DAC platform pairs antibody-based targeting with our degrader expertise to direct protein degradation to specific cell types, and this scientist will play a central role in defining how candidate molecules move through the in vitro assay cascade - from primary screening through mechanistic pharmacological characterization.

This is a lab-based role for someone who wants to bring their own expertise in designing and running in vitro pharmacology studies into an established, highly collaborative discovery organization. The scientist will design, execute, and analyze cellular assays that characterize DAC activity, and will partner closely with discovery biology, conjugation chemistry, analytical biochemistry, DMPK, and automation to advance candidates from early screening. The ideal candidate will be self-driven, resourceful, and organized, and will enjoy shaping assay strategy in a dynamic team environment.

Responsibilities

• Design, build, and optimize the in vitro pharmacology assay cascade for DACs and biologics, from primary screening through mechanistic and quantitative characterization.
• Develop and perform cell-based assays to characterize DAC and biologic activity, including antigen binding, target engagement, and targeted protein degradation, using cutting-edge technologies and automated workflows.
• Cultivate and maintain mammalian cell lines (experience manipulating cell surface antigens and engineering reporter lines used to characterize DACs is preferred).
• Collaborate with team members to contribute to the design and execution of pharmacology studies to assess the biological activity and mechanism of action of lead molecules and drug candidates.
• Stay current with the latest scientific literature and industry developments in the fields of ADCs, DACs, biologics, and targeted protein degradation.
• Analyze, interpret, and clearly communicate results; present findings at internal meetings and contribute to scientific discussions that drive project advancement.
  
  
  

Qualifications

• Ph.D. in a relevant scientific field (Biochemistry, Pharmacology, Biology, etc.) with a strong academic track record, or MS with 6 or more years of relevant industry experience.
• Demonstrated experience designing and setting up in vitro pharmacology studies and screening cascades; prior know-how in building screening/assay cascades in the ADC or DAC field is preferred.
• Hands-on experience with mammalian cell culture and the ability to independently execute, analyze, and report results of quantitative cellular assays relevant to conjugate characterization (e.g., luminescence-based degradation, viability, or internalization assays).
• Experience with mechanistic assays that dissect DAC activity, such as antibody binding and intracellular drug release, is highly desired.
• Familiarity with automation equipment (e.g., liquid handlers) and automated workflows.
• Strong analytical and problem-solving skills, with sound judgment in evaluating and interpreting experimental
  
  
  

Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view
  
  
  

Salary Range: $127K - 143K

Location: Brisbane, CA (Onsite role)

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