Scientist, Bioanalytical - San Diego, CA

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We are seeking a motivated, versatile, detail-oriented Scientist to join the Bioanalytical Team. The focus will be PK, immunogenicity, and cell-based assays at our state-of-the-art lab in San Diego, CA. The successful candidate must have industry experience in biological assay development and be skilled, in method development/qualification/validation and all bioanalytical aspects of biologics drugs.

Responsibilities

• This lab-based position will conceptualize and perform PK, immunogenicity, and cell-based assays including but not limited to support detection of Anti-Drug Antibodies (ADAs), use of Idiotypic antibodies for PK/ADA assays, ligand-binding and neutralization assays in both the regulated and non-regulated environment to support biologics drug candidates (monoclonal and bispecific antibodies) in pre-clinical and clinical development.
• Conduct lab work and collaborate with CROs and CMOs to develop, validate, and execute bioanalytical and cell-based potency assays, as well as interpret and report results to support drug discovery and clinical development activities.
• Collaborate internally with immunology, protein engineering, CMC, clinical development teams, and work closely with multiple external contract organizations including contract laboratories and CMOs in the areas of method transfer, qualification/validation and implementation of QC methods.
  
  
  

Experience And Qualifications

• Bachelor’s degree in biology/biochemistry or related discipline
• 8 or more years of biotechnology/pharmaceutical industry experience in bioanalytical assay development or Master’s degree with 6 or more years of relevant
• Knowledge and hands-on experience with method development, qualification, and validation of cell-based bioassays for potency measurement to support GMP manufacturing, product characterization, lot release, and stability testing are required.
• Experience collaborating with CROs.
• Strong knowledge of immunoassay (plate-based and cell-based assay) development, execution and troubleshooting, as well as hands-on experience in immunoassay technologies, such as ELISA (direct and indirect sandwich formats), Luminescence, Colorimetric, Electrochemiluminescence (MSD), etc. to support preclinical and clinical studies.
• Familiarity with GLP, GCP, Bioanalytical and Immunogenicity Guidance (FDA/EMA) is desirable.
  
  
  

Skills And Abilities

• Independent, self-motivated life scientist with the ability to generate scientific questions and design experiments to address them.
• Excellent problem-solving, analytical and organizational
• Strong interpersonal and communication skills including presenting data to all levels of the
• Understanding of global health authority expectations in bioanalytical space for biologics drug development and registration in immunology/inflammation therapeutic area.
• Demonstrates scientific rigor and curiosity to address scientific questions and design experiments to test a working hypothesis.
• Ability to work in a fast-paced and matrix environment to meet project
  
  
  

The expected base pay range for this position is $110,000 – $135,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

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