Principal Research Scientist I, In Vivo Antibody Discovery

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Job Description

The Biotherapeutics and Genetics Medicine department within Discovery Research isseekinga highly motivated PrincipalScientist to jointheinvivoantibody discovery team at AbbVie Bioresearch Center (ABC). The ABC site in Worcester, MA, offers a unique setting where Biotherapeutics discovery, development and manufacturing coexist in one location. The team partners with multidisciplinary groups across AbbVie focused on developing therapies for Immunology,Neuroscience, and Oncology. Weutilizeinnovative approaches for antibody discoveryincludingcustom immunization strategies, advanced multiplex screening assays, and best-in-class automation platforms to enable successful antibody discovery against challenging targets.

As a member oftheinvivoantibody discovery group, you willbe responsible forleadinginnovative immunization-based antibody discovery. You will provide technical and strategic leadership across multiple immune discovery platforms, driving the identification of high-quality therapeutic antibody candidates for challenging targets and advanced antibody modalities. The successful candidate will combine deepexpertisein antibody discovery technologieswith strong program leadership, cross-functional collaboration, and external partner management.

Key Responsibilities

• Lead antibody discovery programs from hit identification, screening, leadselection, and candidatenomination.
• Design and executenovelantigen engineering strategiesandimmunization approaches, to maximize immune response quality and diversity.
• Provide technical leadership across multiple antibody discovery platforms, including B cell-based discovery, immune repertoire screensand hybridoma
• Lead identification of antibody and VHH modalities for diverse therapeutic programs andmultispecifics.
• Evaluate and implement emerging antibody discovery technologies, including AI-enabled workflows, machine learning, computational biology, and laboratory automation, to expand platform capabilities and accelerate discovery.
• Direct hybrid discovery campaigns that integrate internal capabilities with externalpartners while proactivelyidentifyingand mitigating scientific/operational risks.
• Mentor scientists andprovidetechnical guidance across antibody discovery programs.
• Contribute to the scientific reputation of the organization through publications, patents, presentations, and external collaborations.
  
  
  

Qualifications

• BS, MS, or PhD in immunology,biochemistry,molecular biology,bioinformaticsor a related scientific field with typically 6 (PhD), 12 (MS), or 14 (BS) years ofindustryexperience.
• Deep hands-onexpertisein antibody discovery platforms, such as single B cell cloning, immune repertoire screeningandhybridoma.
• Extensive experience designing antigens and novel immunization strategies for challenging therapeutic targets.
• Strongexpertisein hit identification, screening cascade design, lead triage, and leadselection.
• Experience with VHH discovery platforms using camelids and transgenics.
• Working knowledge of antibody engineering principles, developability assessment, andsequenceliability evaluation.
• Adept atidentifyingand working with novel solutionssuch as AI-based antigen design, and laboratory automation.
• Demonstrated ability to critically evaluate and implement new antibody discovery technologies and methodologies.
• Team playerwithprovenflexibility to deal with changing timelines and shifting work priorities.
  
  
  

Desired

• Experience with rabbit antibody discoveryworkflows.
• Knowledge ofbioinformatics pipelines and concepts used to analyze NGS data.
• Familiarity with computational antibody discovery, AI/ML-enabled design, and laboratory automation technologies.
• Proven ability to lead multidisciplinary discovery teams across biology, protein sciences, engineering, computational sciences, and project management.
• Strong organizational and project leadership skills withdemonstratedsuccess delivering complex discovery programs.
  
  
  

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term and long-term incentiveprograms.
  
  
  

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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