Demo

Principal Research Scientist, Analytical Chemistry

BioSpace
South San Francisco, CA Full Time
POSTED ON 9/19/2026
AVAILABLE BEFORE 10/19/2026
Non-Solicitation Policy And Notice To Agencies And Recruiters

IDEAYA's Non-Solicitation Policy strictly prohibits agencies and recruiters from any contact and communication with IDEAYA employees, managers, and leaders to submit unsolicited candidate resumes and/or to solicit business partnerships. Submission of unsolicited candidate resumes by agencies or recruiters with or without a contract in place with IDEAYA Biosciences Inc. will not create any implied obligation. Failure to comply with this policy will result in disqualification from current and future business opportunities with IDEAYA Biosciences. All recruiting and talent agency decisions are strictly managed by the internal IDEAYA Human Resources function. All communication by external agencies and recruiters must be directed to humanresources@ideayabio.com. We ask that you only email your interest once.

Job Summary

About IDEAYA Biosciences:

IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class, targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody-drug conjugates, or ADCs, for molecularly defined solid tumor indications. Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer.

When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use teamwork to move science forward. For more information, please see www.ideayabio.com.

Location: South San Francisco, CA.

Position Summary

We are seeking a talented and highly motivated individual with significant pharmaceutical industry experience to join our multidisciplinary team and help oversee all aspects of discovery analytical work. The successful candidate will work collaboratively with medicinal chemistry and related cross-functional teams to successfully deliver drug discovery pipeline goals. The responsibilities will include, but not be limited to, those listed below.

This position is based in our South San Francisco headquarter offices and required to be onsite four days per week per our company policy.

Reporting to: Vice President, Medicinal Chemistry

Job Description

What you’ll do:

  • Oversee small molecule analytical chemistry efforts across the IDEAYA discovery portfolio
  • Manage and execute compound purifications (including chiral SFC separations), structural elucidations, biophysical property determinations (such as solubility, logD, and pKa determinations), and stability studies
  • Manage junior analytical chemist(s) to achieve strong productivity with high quality and scientific rigor
  • Ensure existing methods are technically sound, well developed and fit-for purpose
  • Troubleshoot methods and provide technical guidance across discovery programs
  • Manage installation and maintenance of lab analytical equipment.
  • Perform vendor review and selection and provide oversight of all analytical work at external CROs
  • Proactively communicate with and work closely with other functions to help align analytical strategy and achieve goals
  • Help hire high-caliber analytical chemists as needed to build and grow a world-class analytical department
  • Stay aware of newly emerging techniques and technologies and bring new capabilities online as necessary


Requirements

  • Ph.D. in analytical chemistry or related discipline with minimum of (5) years of drug discovery experience with demonstrated ability operating successfully within cross-functional groups
  • Strong subject matter expertise in small molecule purification (both HPLC and SFC essential), physicochemical analysis, analytical method development/validation, and CRO management is essential
  • Additional experience with small molecule structural elucidation techniques is preferred
  • Strong problem-solving skills and ability to quickly adapt and shift focus as needed
  • Stronginterpersonal and communication skills and the ability to work within project teams
  • Ability to multi-task in a fast-paced dynamic environment while demonstrating a calm and positive attitude and a superior work ethic
  • Ability to supervise and mentor junior level associates and/or scientists, including direct reports or supporting team members


All employees are expected to act with integrity and in full compliance with applicable laws, regulations, and IDEAYA policies, including IDEAYA’s Code of Conduct.

Employees must demonstrate good judgement and ethical behavior in all business activities, maintain patient and product safety as a top priority, and report any suspected violations of law or Company policy through appropriate channels

Total Rewards

Along with our inspiring mission, and highly collaborative and inclusive environment, IDEAYA offers a competitive total rewards package that reflects our pay-for-performance philosophy where employees are eligible to be considered for merit-based salary increases, company discretionary short-term incentive plan participation, and company discretionary stock option awards (based on board approval). Our comprehensive benefits package includes, but is not limited to, medical/dental/vision coverage (100% company paid for employees and 90% company paid for dependents), 401k, ESPP, and wellness programs.

The expected salary range for the roleof the Principal Research Scientist, Analytical Chemistry is $167,000 - $206,000. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the office location where this open position is located, the final candidates’ experience within their profession, experience in the disease areas we are striving to make an impact in as a company, length of time within the industry, educational background, and performance during the interview process.

The Company complies with all laws respecting equal employment opportunities and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.

IDEAYA is an equal opportunity employer. In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets.

Salary : $167,000 - $206,000

If your compensation planning software is too rigid to deploy winning incentive strategies, it’s time to find an adaptable solution. Compensation Planning
Enhance your organization's compensation strategy with salary data sets that HR and team managers can use to pay your staff right. Surveys & Data Sets

What is the career path for a Principal Research Scientist, Analytical Chemistry?

Sign up to receive alerts about other jobs on the Principal Research Scientist, Analytical Chemistry career path by checking the boxes next to the positions that interest you.
Income Estimation: 
$116,765 - $144,626
Income Estimation: 
$142,836 - $179,016
Income Estimation: 
$112,363 - $146,135
Income Estimation: 
$153,127 - $203,425
Income Estimation: 
$139,626 - $193,276
Income Estimation: 
$164,650 - $211,440
Income Estimation: 
$130,030 - $173,363
Employees: Get a Salary Increase
View Core, Job Family, and Industry Job Skills and Competency Data for more than 15,000 Job Titles Skills Library

Job openings at BioSpace

  • BioSpace Home, KS
  • Company Overview Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are... more
  • 11 Days Ago

  • BioSpace Home, KS
  • Company Overview Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are... more
  • 11 Days Ago

  • BioSpace Home, KS
  • Company Overview Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are... more
  • 11 Days Ago

  • BioSpace Home, KS
  • Company Overview Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are... more
  • 11 Days Ago


Not the job you're looking for? Here are some other Principal Research Scientist, Analytical Chemistry jobs in the South San Francisco, CA area that may be a better fit.

  • Thermo Fisher Scientific South San Francisco, CA
  • This job is with Thermo Fisher Scientific, an inclusive employer and a member of myGwork – the largest global platform for the LGBTQ+ business community. P... more
  • 1 Month Ago

  • SonoThera South San Francisco, CA
  • About SonoThera: SonoThera is a venture-backed genetic medicine company advancing ultrasound-mediated, non-viral targeted therapies to unlock the full pote... more
  • 1 Month Ago

AI Assistant is available now!

Feel free to start your new journey!