Senior Researcher

Research Associate / Senior Research Associate, Research & Early Development

Location: Irvine, CA (On-site)

We are seeking a highly motivated Research Associate or Senior Research Associate to join a Research & Early Development team. This is a hands-on bench role for an experienced industry scientist who thrives in a fast-paced environment, takes pride in data quality, and is ready to contribute from day one.

The ideal candidate will have direct industry experience in T Cell Engager or broader immune-oncology programs and be highly proficient in assays used for screening and characterization. This is an execution-focused role for someone who is technically sharp, detail-oriented, reliable, and comfortable working collaboratively within a small team.

Responsibilities

• Execute a broad range of in vitro assays for screening and characterization of T Cell Engager candidates.
• Perform tumor-directed cytotoxicity assays, immune cell profiling by flow cytometry, cytokine analysis by ELISA and multiplex platforms, and T cell proliferation and activation assays.
• Conduct cell surface binding assays and support cell engineering efforts, including target antigen quantification, expression, and knockdown.
• Maintain routine mammalian cell culture of tumor cell lines and handle primary immune cells as needed, including PBMCs, T cells, and NK cells.
• Support assay development and optimization.
• Troubleshoot experimental issues and communicate observations clearly and promptly.
• Perform routine data analysis using GraphPad Prism and Excel, including curve fitting and basic statistical analysis.
• Maintain accurate experimental records in an electronic lab notebook system.
• Prepare clear data summaries for team meetings and contribute to slide deck updates.
• Support day-to-day lab operations, including reagent and frozen cell inventory management, equipment upkeep, and SOP compliance.

Qualifications

• B.S. in immunology, cell biology, biochemistry, or a related field.
• 3–5 years of hands-on industry experience in a biotech or pharma research setting.
• Direct experience with T Cell Engager or immune-oncology programs and related assays.
• Proficiency in mammalian cell culture, ELISA, and multiplex cytokine assays.
• Strong experience with TDCC, T cell activation, PBMC/NK cell-based assays, and flow cytometry-based profiling.
• Strong attention to detail, organizational skills, and record-keeping habits.
• Collaborative mindset and comfort working in an execution-focused role.
• Experience with BLI-based binding assays, Benchling, or cell engineering techniques is a plus.
• Hands-on mouse study experience is a plus, though in vivo work is not currently part of the role.

What We’re Looking For

• Someone who can contribute quickly without extensive ramp-up.
• A humble team player who communicates openly and works well in a small, fast-paced environment.
• A scientist who enjoys bench work and wants to directly support pipeline progress.