What are the responsibilities and job description for the Scientist II, Yeast Display position at BioPhase Solutions?
BioPhase Solutions specializes in recruiting top talented professionals for Southern California's Scientific community. We are currently looking for a Scientist II, Yeast Display to work for an Greater Los Angeles area biotechnology company.
$118-150k /year depending on experience
Summary:
We are seeking a highly motivated and skilled individual to join our client's Antibody Discovery team. This open position is an exciting opportunity to impact the next wave of biologic candidates to enter our pipeline. The successful candidate should have general in vitro antibody display experience with special emphasis on yeast display. The ideal candidate will work to optimize a yeast-display discovery platform and participate in antibody library design and construction. The candidate will collaborate with scientists from different functional groups and conduct in vitro display campaigns to identify novel therapeutic hits and optimize leads against a wide range of targets and diseases. Candidates should have a demonstrated record of technical proficiency and ability to work effectively with a diverse group of researchers in a team environment.
Responsibilities:
- Perform yeast display-based discovery screens to support new and ongoing therapeutic programs.
- Use NGS, including NGS library generation, QC, sequencing and data analysis, for hit selection.
- Execute display-based lead optimization, including design and building of new display libraries, QC, and screening.
- Stay current with external advancements in relevant scientific fields and techniques.
- Evaluate scientific strategies, review data in real-time and make the necessary experimental adjustments to ensure successful delivery of yeast display discovery campaigns.
- Coordinate research & development efforts with other departments to prioritize critical experiments for advancing discovery programs.
- Participate and presents data in group and departmental meetings as needed.
- Follow all laboratory safety guidelines, practices and protocols.
- Contribute to the design and execution of experiments, analysis, interpretation of data, and reporting and archiving of results.
- Adhere to all department and company-wide policies regarding conduct, performance and procedures.
- May provide direction to direct and indirect reports, as applicable, in accordance with the organization’s policies and procedures.
- Attend to daily laboratory operations including the maintenance of equipment, inventories, consumables, reagents, and other supplies.
- Performs other duties as required.
Qualifications:
- Ph.D. in a relevant scientific field, with at 3 years of post-graduate laboratory work experience; previous industry experience is preferred.
- Requires prior experience collaborating on project teams matrixed across functions including contract laboratories and corporate partners and strong research study experience.
- Requires sound theoretical and experimental experience in a relevant scientific field coupled with technical proficiency, scientific creativity, collaboration with others and independent thought. Small company and industry work experience preferred.
- Strong hands-on experience with yeast display, including building naïve and/or immunized libraries.
- Experience with antibody lead optimization, including affinity, potency and developability enhancement.
- Expertise in molecular cloning and utilization of DNA analysis software (Geneious Prime, Sequencher or similar software).
- Experience in NGS technology, including NGS library generation, QC, sequencing and sequence analysis.
- Experience with AI / ML sequence analysis would be helpful.
- Strong understanding of antibody structure, function, and engineering.
- Experience with high throughput screening (96 and 384-well plates) and liquid handling automation is desirable.
- Excellent verbal and written communication skills; ability to communicate clearly and effectively with scientific colleagues and management by contributing sound scientific concepts, ideas and direction.
- Significant analytical, assessment and problem-solving skills.
- Ability to perform method development, write protocols, maintain detailed records, and use an electronic notebook are required. Experience with Benchling as an ELN and database is desirable.
- Ability to read, analyze, interpret and communicate complex data and information.
- Proficiency in software and data analysis packages like Microsoft Office (Word, Excel, Outlook, PowerPoint), Spotfire, FloJo and GraphPad Prism.
Please send resumes to idan@biophaseinc.com and visit our website at www.biophaseinc.com for additional job opportunities!!!
Salary : $118,000 - $150,000