What are the responsibilities and job description for the Scientist, ADC Chemistry position at BioNTech SE?
Cambridge, US | full time | Job ID: 10595
Position Summary
BioNTech is developing novel Antibody-Drug Conjugates (ADCs) and other targeted therapeutics for the targeted treatment of cancer with the goal of maximizing efficacy and minimizing toxic effects to patients. To achieve this goal ADCs and/or degraders will be prepared, evaluated in a battery of in vitro and in vivo assays, then based on results, improved therapeutics will be developed.
As a Chemistry Scientist in Global ADC Innovation Unit, you will help design and synthesize the payloads, linkers, and linker-payloads required to generate next generation ADCs. You may also be involved in the conjugation step, attaching linker-payloads to various antibodies. You will work closely with team members who have diverse backgrounds in Biology, Pharmacology and other disciplines. You will also prepare presentations for the team, and possibly for upper management, including progress updates and proposals for linker-payload improvements.
Primary Responsibilities
Your Benefits:
BioNTech US is committed to employee wellbeing and offers best-in-class benefits & HR programs to support an inclusive & diverse workforce. Salaried/Position-Targeted Hourly Employees working 30 hours per week are eligible for our comprehensive benefits package. Benefits include but are not limited to:
Home to dozens of research institutions, biopharmaceutical companies, life science incubators, venture capital firms, and over 30 million square feet of laboratory space, Cambridge, Massachusetts has earned a reputation as the #1 life science cluster in the world. As part of the Greater Boston area, the city is often referred to as the "biotech supercluster" due to its high concentration of life sciences firms. This unique ecosystem is the result of a model partnership between academia and industry, fostering collaboration and innovation and driving the development of new therapies, medical devices, and diagnostics. As Cambridge’s thriving life sciences industry continues to evolve, the city remains a beacon of knowledge, innovation, and collaboration, poised to shape the future of science and technology.
Apply now - We look forward to your application!
Apply for our Cambridge, US location and simply send us your documents using our online form.
By submitting your application, you acknowledge that a background check will be conducted as part of the recruitment process in accordance with applicable laws and regulations. If you are considered for the position, BioNTech will conduct the background check through our service provider ‘HireRight’. You will be informed accordingly by your BioNTech-Recruiter.
Position Summary
BioNTech is developing novel Antibody-Drug Conjugates (ADCs) and other targeted therapeutics for the targeted treatment of cancer with the goal of maximizing efficacy and minimizing toxic effects to patients. To achieve this goal ADCs and/or degraders will be prepared, evaluated in a battery of in vitro and in vivo assays, then based on results, improved therapeutics will be developed.
As a Chemistry Scientist in Global ADC Innovation Unit, you will help design and synthesize the payloads, linkers, and linker-payloads required to generate next generation ADCs. You may also be involved in the conjugation step, attaching linker-payloads to various antibodies. You will work closely with team members who have diverse backgrounds in Biology, Pharmacology and other disciplines. You will also prepare presentations for the team, and possibly for upper management, including progress updates and proposals for linker-payload improvements.
Primary Responsibilities
- Work with a team designing and producing novel ADC payloads, ADC linkers, ADCs and other targeted therapeutics
- Design, synthesize, and purify small molecules, linkers, potent payloads, and potentially conjugate them to proteins.
- Work in a safe manner, using appropriate containment for potent compounds.
- Use NMR and HPLC/UPLC techniques to prove the identity and purity of prepared compounds
- Prepare presentations and work cross-functionally within the organization in various areas including formulation, drug delivery, pharmacokinetics, and pharmacodynamics
- Liaise with BioNTech partners, CROs and CDMOs
- Ph.D. in synthetic organic chemistry, with 3 years of industry experience developing ADC payloads, ADC linkers, and ADCs.
- Hands-on experience preparing complex organic molecules and using HPLC, LC-MS and NMR for purification/analysis
- Proven track record of creative thinking and consistent delivery as demonstrated by publications and presentations
- Excellent interpersonal, networking, and communication skills
- Must be able to work on site in our synthetic laboratory
- Experience with analytical methods used in ADC payload, ADC linker and ADC development
- Experience in molecular modeling
- Experience in degrader chemistry
Your Benefits:
BioNTech US is committed to employee wellbeing and offers best-in-class benefits & HR programs to support an inclusive & diverse workforce. Salaried/Position-Targeted Hourly Employees working 30 hours per week are eligible for our comprehensive benefits package. Benefits include but are not limited to:
- Medical, Dental and Vision Insurance
- Life, AD&D, Critical Illness Insurance
- Pre-tax HSA & FSA, DCRA Spending Accounts
- Employee Assistance & Concierge Program (EAP) available 24/7
- Parental and Childbirth Leave & Family Planning Assistance
- Sitterstream: Virtual Tutoring & Childcare Membership
- Paid Time Off: Vacation, Sick, Bereavement, Holidays (including Floating) & Year-End U.S. Shutdown.
- 401(K) Plan with Company Match
- Tuition Reimbursement & Student Loan Assistance Programs
- Wellbeing Incentive Platforms & Incentives
- Professional Development Programs
- Commuting Allowance and subsidized parking
- Discounted Home, Auto & Pet Insurance
Home to dozens of research institutions, biopharmaceutical companies, life science incubators, venture capital firms, and over 30 million square feet of laboratory space, Cambridge, Massachusetts has earned a reputation as the #1 life science cluster in the world. As part of the Greater Boston area, the city is often referred to as the "biotech supercluster" due to its high concentration of life sciences firms. This unique ecosystem is the result of a model partnership between academia and industry, fostering collaboration and innovation and driving the development of new therapies, medical devices, and diagnostics. As Cambridge’s thriving life sciences industry continues to evolve, the city remains a beacon of knowledge, innovation, and collaboration, poised to shape the future of science and technology.
Apply now - We look forward to your application!
Apply for our Cambridge, US location and simply send us your documents using our online form.
By submitting your application, you acknowledge that a background check will be conducted as part of the recruitment process in accordance with applicable laws and regulations. If you are considered for the position, BioNTech will conduct the background check through our service provider ‘HireRight’. You will be informed accordingly by your BioNTech-Recruiter.
Salary : $99,100 - $158,700