What are the responsibilities and job description for the Principal Research Associate, mRNA Process Development position at Beam Therapeutics?
Company Overview
Beam Therapeutics is a biotechnology company committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform that includes a suite of gene editing and delivery technologies and is in the process of building internal manufacturing capabilities. Beam’s suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of potential therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.
Position Overview:
Beam is seeking a highly talented and motivated Principal Research Associate to join our growing mRNA Process Development team. The Principal Research Associate will be responsible for executing late-stage mRNA process development activities, with a focus on downstream purification. The individual will have the opportunity to work with a dynamic and collaborative team across a range of technical areas. They will be tasked with supporting experimental design, execution and data analysis as well as authoring technical documents and reports.
This role is onsite 5 days/week in Cambridge, MA
Responsibilities:
- Support the design and execution of mRNA purification studies to support process development
- Use DoE and other statistical tools to help characterize our processes and to develop control strategies
- Help manufacture materials for use in process development
- Support external and internal tech transfers
- Effectively document, interpret and communicate technical results
- Work cross-functionally to support Beam programs to ensure critical timelines are met
Qualifications:
- Bachelor’s or Master’s Degree in related science with 10 years of relevant experience (e.g. chemical engineering, biochemical engineering, biochemistry etc)
- Experience with mRNA purification technologies is preferred (chromatography and TFF)
- Knowledge of mRNA manufacturing processes
- Highly organized and detail oriented with strong communication skills
- Motivated to learn and to execute process development studies in the lab
- A collaborative mindset
