What are the responsibilities and job description for the Synthetic Organic Chemist position at Beacon Hill?
Position Summary:
We are seeking a highly skilled and motivated scientist with expertise in synthetic organic chemistry to join our team in advancing the discovery and development of novel small molecules. As a key member of the synthetic chemistry group, you will collaborate closely with medicinal chemists and external CRO partners to design, synthesize, and characterize drug-like compounds optimized for potency, selectivity, pharmacokinetics, and efficacy, with the goal of advancing candidates into human clinical trials.
Required Qualifications:
Educational Background:
- M.S. or Ph.D. in Synthetic Organic Chemistry with 1 years of experience in the biotechnology or pharmaceutical industry, specifically within a chemistry department.
Technical Expertise:
- Deep knowledge of organic synthesis, with familiarity with current literature and modern synthetic reactions and methodologies.
- Proven ability to design robust, multi-step synthetic routes that allow for late-stage diversification.
- Strong problem-solving skills with the creativity to troubleshoot and optimize complex reactions independently.
- Experience running reactions in parallel to efficiently deliver final compounds in batches.
- Proficiency in medium-scale synthesis to prepare key intermediates.
- Skilled in the purification and characterization of intermediates and final compounds using modern techniques (e.g., NMR, LC-MS).
Documentation and Reporting:
- Ability to maintain high-quality, detailed experimental records in electronic notebooks (e-notebooks), ensuring data is suitable for publications and patent filings.
Collaboration and Communication:
- Team-oriented, with strong interpersonal skills to exchange information effectively and contribute to a collaborative work environment.
- Scientific curiosity and enthusiasm for contributing to a dynamic research setting.
- Excellent verbal and written communication skills, capable of presenting rationale, key data, challenges, and accomplishments clearly to internal teams and external collaborators (e.g., CROs).
CRO Interaction:
- Demonstrated ability to interface with and guide CRO chemists to achieve high efficiency and productivity in synthetic activities.
