Surface Chemist

Surface Chemist

W2 Contract

Pay Rate: $55 - $65 per hour

Location: Berkeley, CA - Onsite Role

Job Summary:

As a highly skilled and experienced Surface Chemist, you will be responsible for developing solid-phase supports for a novel sequencing platform. This role reports to the Senior Director of Chemistry and requires expertise in surface chemistry, solid-phase synthesis, and analytical techniques. The successful candidate will work independently in a laboratory environment and collaborate effectively with cross-functional teams.

Duties and Responsibilities:

• Develop solid supports that meet the physicochemical performance requirements for a novel single-molecule protein sequencing workflow and will be compatible with automation equipment.
• Source and synthesize custom supports to investigate surface functionalization, porosity, size, stability, and manufacturability.
• Optimize functionalization chemistries (includes covalent, cleavable, linkers, passivation) to improve interfacial reaction kinetics and efficiency and assay signal-to-noise.
• Develop and validate analytical methods to characterize/QC solid supports.
• Develop and validate functional testing methods to characterize/QC solid supports.
• Partner with scientists and engineers to deploy novel supports into SOP workflows.
• Design and execute experiments bridging chemistry and molecular biology.
• Analyze experimental data, generate detailed reports, and provide actionable insights to guide further development.
• Apply statistical methods and process evaluation tools to ensure workflow quality and performance.
• Prepare and maintain comprehensive documentation of protocols, SOPs, and results.
• Contribute to process innovation and support technology transfer as workflows mature.

Requirements and Qualifications:

• Degree in organic chemistry, surface chemistry, bioengineering, or equivalent field; advanced degree preferred.
• 1 years (PhD), 3 years (MS), 5 years (B.S.) of industry or equivalent experience in assay or reagent development.
• Demonstrated proficiency in surface and morphological characterization (AFM, SEM/TEM, XPS, contact angle, DLS, zeta potential).
• Expertise in surface and solid-phase chemistry, including surface modification, functional group coupling (and quantitation), and polymer or nanoparticle surface engineering.
• Experience with atom transfer radical polymerization (ATRP) for grafting and tailoring polymer brushes or coatings on surfaces and particles.
• Demonstrated proficiency in analytical characterization, including LC-MS, HPLC, FTIR, UV-Vis, fluorescence spectroscopy, and elemental analysis.
• Hands-on experience with bioconjugation chemistry, such as coupling of proteins, peptides, small molecules, or oligonucleotides via covalent or affinity-based linkers.
• High-throughput screening (HTS) using methods such as combinatorial synthesis arrays with automated characterization.
• The ideal candidate will have a proven track record developing functionalized beads from scratch (synthesis, characterization, and validation) through to successful deployment in a downstream assay.
• Excellent problem-solving skills and attention to detail.
• Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds.
• Ability to thrive in a fast-paced environment with evolving priorities.

Bayside Solutions, Inc. is not able to sponsor any candidates at this time. Additionally, candidates for this position must qualify as a W2 candidate.

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Desired Skills and Experience

Surface Chemistry, Surface Characterization, Morphological Characterization, AFM, SEM, TEM, XPS, Contact Angle Measurement, Dynamic Light Scattering, DLS, Zeta Potential, Solid-Phase Chemistry, Surface Modification, Functional Group Coupling, Polymer Surface Engineering, Nanoparticle Surface Engineering, Atom Transfer Radical Polymerization, ATRP, Polymer Brushes, Surface Coatings, Analytical Characterization, LC-MS, HPLC, FTIR, UV-Vis Spectroscopy, Fluorescence Spectroscopy, Elemental Analysis, Bioconjugation Chemistry, Protein Conjugation, Peptide Conjugation, Small Molecule Conjugation, Oligonucleotide Conjugation, Covalent Linkers, Affinity-Based Linkers, High-Throughput Screening, HTS, Combinatorial Synthesis, Automated Characterization, Functionalized Beads, Bead Synthesis, Assay Development, Assay Validation