What are the responsibilities and job description for the Associate Scientist, BioAssay position at Aurora Therapeutics?
ABOUT THE COMPANY
Aurora Therapeutics is transforming the development and approval of personalized gene-editing therapies for patients with rare diseases. The company utilizes advanced CRISPR technologies alongside innovative regulatory and manufacturing frameworks to streamline the path for multiple mutation-specific treatments. Aurora's innovative approach overcomes traditional barriers to delivering therapies for rare mutations, enabling CRISPR treatments to serve larger patient populations. For more details, visit auroratherapeutics.com.
Aurora was founded by Jennifer Doudna, Ph.D., CRISPR co-inventor and Nobel Laureate, and Fyodor Urnov, Ph.D., a leader in translating genome-editing science into human therapeutics. Our experienced leadership team led by Edward M. Kaye, M.D., brings deep expertise in both gene editing and clinical development.
ABOUT THE ROLE
Aurora is expanding our research team and seeking an Associate Scientist in Bioanalytical Sciences. We're looking for a motivated scientist to join our team and contribute directly to advancing our first therapeutic program. This is an opportunity to make meaningful contributions at a critical stage of our pipeline development. This is a full-time, on-site role for an Associate Scientist in Bioanalytical Sciences, based in Cambridge, MA.
RESPONSIBILITIES
- Develop, qualify, and validate PK/PD assays (RT-qPCR/ddPCR, ELISA/MSD, NGS-based editing readouts) following ICH M10 and FDA bioanalytical guidance to support preclinical studies
- Process and analyze mouse and NHP tissues, optimizing workflows for nucleic acid and protein extraction from liver and other organs, as well as downstream molecular analysis
- Author and maintain assay protocols, SOPs, and technical reports to GLP-ready standards
- Support transfer of qualified assays to external CRO partners and troubleshoot technical issues
- Generate and analyze bioanalytical data to inform lead selection, dose optimization, and study design
- Maintain rigorous electronic lab notebooks, sample inventories, and data documentation
QUALIFICATIONS
Required:
- B.S. with 5 years or M.S. with 3 years of relevant laboratory experience in molecular biology, biochemistry, genetics, or a related discipline
- Hands-on expertise with LBA and PCR assay development, optimization, and troubleshooting for protein and mRNA quantification
- Proficiency in additional molecular and immunoassay techniques: DNA/RNA isolation from tissues, RT-qPCR/ddPCR, NGS, ELISA or MSD platforms
- Experience processing mouse and/or NHP tissues for downstream molecular analysis
- Experience writing detailed protocols and technical documents
- Strong organizational skills with meticulous attention to data integrity and documentation
Preferred:
- Biotech or pharmaceutical industry experience, particularly in preclinical bioanalysis
- Familiarity with ICH M10 guidelines and regulated bioanalytical method development
- Tissue processing experience with high-throughput platforms (e.g., bead-based homogenization, automated extraction systems, 96-well workflows)
- Experience with CRISPR-based gene editing assays including NGS library prep for editing quantification
- Cell culture experience including sterile technique, transfection, and primary cell handling. Experience with primary human hepatocytes is preferred.
- Experience with CRO management or assay technology transfer
- Exposure to LNP-based in vivo gene editing therapeutics
To apply, submit your resume/CV and cover letter to careers@auroratherapeutics.com.
EQUAL OPPORTUNITY STATEMENT
Aurora Therapeutics is committed to diversity and inclusivity in the workplace.