What are the responsibilities and job description for the Global Translational Medicine Lead - Oncology position at Astellas?
Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!
Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com.
This position is based in Northbrook, Illinois. Remote work from certain states may be permitted in accordance with Astellas’ Responsible Flexibility Guidelines. Candidates interested in remote work are encouraged to apply.
Purpose and Scope:
Lead the development and execution of Translational Medicine strategy to advance Astellas’ Oncology projects. Candidates should have deep expertise in ophthalmology, vision science, and retinal diseases and record of accomplishment in developing and executing translational strategy from late discovery through clinical development. Ability to represent the TM function and work effectively on cross-functional teams is essential to the success of this position.
Responsibilities and Accountabilities:
- Develops and executes integrated translational science and biomarker development plans and defines patient selection strategies for clinical studies
- Develops and validate biomarkers, imaging readouts, and fluid-based assays relevant to ocular diseases
- Contributes to overall development strategy and trial design, incorporating biomarker endpoints
- Leads Translational Medicine activities and collaborates cross-functionally on asset development teams
- Works with clinical team for implementation of biomarker sample collection and bioanalysis
- Drives clinical biomarker data analysis and interpretation
- Contributes to clinical documents: protocols, IBs, study reports, statistical analysis plans, publications, CSR and biomarker sections of regulatory submissions
- Leads reverse translation, so that clinical results can be used to inform development strategy
- Establishes and leads Translational Medicine focused external collaborations
- Thinks strategically and drives innovation. Evaluates and incorporates emerging technologies and approaches in cell and gene therapy development
Qualifications:
Qualifications:
Required
- Advanced degree (PhD or MD) in ophthalmology, vision science, or a related field
- A minimum of 10 years relevant experience in drug discovery and development in biotech/pharmaceutical company or equivalent translational development experience at an academic institution.
- Breadth of knowledge in cancer biology, cancer genomics, and oncology drug development
- First-hand experience in the identification and validation of pharmacodynamic and patient selection biomarkers, biomarker assay qualification and clinical implementation
- Proven record of leading teams and obtaining high quality and timely results through influencing in a matrix environment
- Demonstrated success in delivering high quality clinical biomarker data to inform decisions and development strategy
- Broad technical experience in DNA, RNA, and protein-based biomarker assays (e.g. PCR, NGS, ELISA/MSD, IHC, IF, Mass spectrometry)
- Experience in fit-for-purpose biomarker assay qualification/validation
- An innovative mindset with track record of incorporating new technologies in translational and biomarker research
- Strong communication skills (oral, written, and presentations), interpersonal, influencing, and overall leadership skills
Preferred:
- Experience with ctDNA analysis
- Strong scientific background in any of the following areas: KRAS biology; tumor drivers; PROTACs/protein degradation
- Experience in solid tumors such as NSCLC, Pancreatic cancer, Colorectal cancer, Prostate cancer
- Experience in managing CROs
Salary Range
$170,450 - $267,850 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience and organizational equity considerations)
Benefits:
- Medical, Dental and Vision Insurance
- Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down
- 401(k) match and annual company contribution
- Company paid life insurance
- Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
- Long Term Incentive Plan for eligible positions
- Company fleet vehicle for eligible positions
- Referral bonus program
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Salary : $170,450 - $267,850