Medical Science Liaison

JOB PROFILE

Ascentage Pharma – Who we are:

Ascentage Pharma: (Nasdaq: AAPG and HKEX: 6855) is a global, clinical-stage biotechnology company engaged in developing novel therapies for cancers and other diseases. Ascentage Pharma is proud of its collaborative, supportive culture, unified by the desire to develop therapeutics that will have a positive impact on patients’ lives. Ascentage Pharma is a dynamic and fast-paced organization that has been responsive to the needs of individual employees throughout its history. The company is defined by a shared understanding it succeeds in advancing its mission only as each individual experiences’ success in their role.

Leveraging our robust internal research and development capabilities, we have built a portfolio of global intellectual property rights. We have also established global collaboration relationships with leading biotechnology and pharmaceutical companies, such as AstraZeneca, Takeda, Innovent, Merck, and Pfizer and research and development relationships with leading research institutions, such as Dana-Farber Cancer Institute, Mayo Clinic, MD Anderson Cancer Center, National Cancer Institute and the University of Michigan. We are a leader in global innovation with a portfolio of more than U.S. and international patents and more than U.S. and international pending applications.

We have assembled a talented, global team with experience in the research and development of innovative drugs, as well as commercial manufacturing, sales and marketing. Our success is shaped by this global team of over to 800 employees across United States, Europe, Australia, and China.

Looking for Candidates in the: Boston, MA; Houston, TX; and Jacksonville, FL region

About the Role

Ascentage Pharma is seeking a high-caliber, strategic Senior to Principal Medical Science Liaison (MSL) to join our US Medical Affairs Department. This is a critical, high-visibility role designed for an expert communicator and scientific strategist who will directly impact on our pipeline's market readiness in the US.

You will not just manage a territory; you will design and execute the regional scientific engagement strategy required to bring our high-value Oncology and Hematology assets to the US market. You will serve as the primary scientific bridge between clinical developments and leading US healthcare providers and institutions.

The successful candidate will follow ethical codes in accordance with the Ascentage Core Values: Patients First, Innovation-Driven, Science Based

Key Responsibilities & Market Launch Focus

• Strategic US KOL Engagement: Identify, map, and cultivate long-term, high-impact relationships with national and regional Key Opinion Leaders (KOLs), academic researchers, and clinical trial investigators to build scientific advocacy.
• US Market Launch Readiness: Support launch readiness initiatives by translating complex clinical trial data into compelling medical value propositions for US payers, formulary committees, and major healthcare networks.
• Scientific Insights & Strategy: Capture, synthesize, and report critical deep-dive field insights to influence US Key Opinion Leaders (KOL) and Global Medical Affairs strategies and asset development.
• Clinical Trial Support: Partner with Clinical Operations to accelerate US-based evidence generation, identify potential clinical trial sites, and facilitate investigator-initiated research (IIR) submissions. Facilitate inquiries in investigator initiated-studies, grant requests, and submissions through internal processes
• Cross-Functional Collaboration: Work closely with internal stakeholders—including Clinical Development, Market Access, and Commercial teams—to ensure seamless execution of the US medical plan. Capture, share, and identify insights from various engagement activities and attend and share insights from key medical/scientific congresses
• US Compliance & Governance: Maintain strict adherence to all US pharmaceutical guidelines, including PhRMA code, OIG regulations, the Sunshine Act, and internal company SOPs.
• Leadership & Mentorship: Provide advanced regional guidance and mentorship to newer or incoming members of the US MSL team.
• Analysis: Provide in-depth competitive scientific analysis of key assets and identify and foster key opportunities for scientific growth and medical evidence generation for support of approved and pipeline products
• Communications: Provide high quality presentations to various audiences, internally and externally, and engage in strategic discussions to advance understanding of relevant therapeutic areas and provide relevant medical and scientific information to meet the needs of the medical and scientific community

Required Qualifications & Experience

• Advanced Degree Required: MD, DO, PharmD, or PhD in a relevant scientific or clinical discipline.
• 2 to 5 Years of MSL Experience: Proven track record as a high-performing MSL within the US pharmaceutical industry (Oncology or Hematology therapeutic expertise is strictly required).
• Proven US Launch Expertise: Demonstrated success in preparing US therapeutic markets for asset launches, navigating FDA approval timelines, and driving early-access or expanded-access programs.
• Mastery of US KOL Dynamics: Advanced, verifiable experience navigating complex US healthcare ecosystems, including major academic medical centers, NCI-designated cancer centers, and community oncology and hematology networks.
• Strategic Communication: Exceptional presentation, writing, and relationship-management skills, with the ability to engage in peer-to-peer strategic discussions with world-renowned clinicians.
• Compliance Expert: Deep knowledge of US ethical codes, compliance standards, and laws governing industry interactions with healthcare professionals.

Location: Ascentage Pharma is based in Rockville, MD, however, this position can be remote in the US.

Why Join Ascentage - Our Value Proposition

This is a rare opportunity to shape the clinical vision of a public biotech at a pivotal growth moment—and see your work make a tangible impact for patients. If you want to do something that matters—this work matters. Patients drive our passion to pioneer novel cancer therapies. Creating and delivering life-changing medicines requires focus, dedication, and heart. We hire exceptional people, trust them to do their best work, and support them with the resources and flexibility to thrive.

What We Offer

• Exciting, supportive, and intellectually challenging global work environment.
• Competitive benefits, including medical, dental, vision, disability, and life insurance. Short-Term and Long-Term disability, parental leave, and a matching 401(k) program (immediate vesting).
• Generous PTO and holidays, as well as floating holidays to encourage balance and recharge.
• Training, International conference attendance and inter-departmental exposure for career growth allowing for leadership opportunities within the company.
• A culture of engagement, diversity, inclusion, and empowerment.
• A culture of collaboration with a focus on professional growth and opportunities.
• Flexibility to work onsite, remotely, or in a hybrid model.
• The chance to work with other talented, and entrepreneurial people who are passionate about achieving excellence in all they do every day, with a shared commitment to science and to the patients we serve

Compensation and Benefits

At Ascentage, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, STD, LTD, 401(k), and more), annual target bonuses and eligibility to receive equity. Actual pay is based on a myriad of factors such as location, experience, skills, education, and internal equity.

About Ascentage Pharma

Ascentage Pharma (NASDAQ: AAPG and HKEX: 6855) is a globally focused, clinical-stage biotechnology company engaged in developing novel therapies for cancers, CHB, and age-related diseases. In January of 2025 Ascentage went public on NASDAQ. In July 2025 we announced that our proprietary novel Bcl-2 selective inhibitor Lisaftoclax has been approved by China’s National Medical Products Administration (NMPA) for the treatment of adult patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. In May of 2026 at ASCO Ascentage Pharma announced that is currently in nine registration trials, four of which are global studies intended for FDA and EMA filings.