Associate Scientist II, Mechanistic Pharmacology

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

Arrowhead is seeking an Associate Scientist to join our growing Biology Department at our Madison site. This is an excellent opportunity to utilize, contribute and advance the ideal candidate’s laboratory skills in a progressive, state-of-the-art and diverse facility.

Responsibilities

• Conduct in vitro studies to facilitate protein assay development in support of drug discovery in various diseases
• Perform protein expression assays as well as functional analysis by various methods
• Develop and implement novel protein expression and enzyme activity assays for target validation
• Perform recombinant protein expression and purification
• Prepare and maintain electronic laboratory notebooks and appropriate data files
• Read and apply relevant scientific literature to projects to troubleshoot and solve problems
• Present research findings to project teams and prepare technical reports
• Maintain a high level of productivity in the lab and perform critical experiments

Requirements

• Bachelor’s in Cell Biology, Molecular Biology, Pharmacology, Biochemistry or a related discipline. 
• 2 years of experience in a biology lab or research lab environment 
• Experience with immunoassays (e.g. ELISA, immunoprecipitation, immunoblot)
• Hands-on experience in cellular and molecular biology techniques, such as RNA and protein isolation, qPCR, as well as cell culture and transfection proficiency
• Demonstrated innovation, creativity and resilience in problem solving
• Data collection, analysis, and detailed record keeping.
• Ability to work independently and to handle multiple projects and deadlines
• Excellent oral and written communication skills
• Self-motivated team player with the ability to thrive in a fast paced, multi-disciplinary environment
• Ability to take direction, follow protocols and produce and communicate results
• Prolonged periods sitting at a desk/lab workstation
• Must be able to lift up to 15 pounds at a time
• Ability to navigate various locations and settings of the company
• Wear personal protective equipment in laboratories and other areas as required

Preferred

• Biotech or pharma industry experience 
• Experience handling tissue samples
• Working knowledge of LC- or GC-MS is a plus
• Experience with protein expression and systems

Wisconsin pay range {{:}} $70,000 USD - $80,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

Candidates must have current, valid authorization to work in the country where this role is located.

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