Associate Scientist II, Bioassays (Molecular Biology)

Arrowhead Pharmaceuticals, Inc. (Nasdaq{{:}}  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

Arrowhead is seeking a highly motivated molecular biologist to join our growing Bioassays team at our Madison site. The Molecular Biology team supports R&D projects across all sites. The ideal candidate should have 1-2 years of cloning experience with the ability to independently work on multiple constructs simultaneously.

Responsibilities

• Support in vitro, ex vivo and/or in vivo studies to facilitate drug discovery and development with some independence
• Propose methods and ways to optimize cloning
• Occasionally present research findings to project teams
• Occasionally read relevant scientific literature and propose applications to projects to troubleshoot and solve problems
• Maintain a high level of productivity and quality in the lab
• Perform critical experiments 
• Primary Molecular Biology Responsibilities{{:}}
  • Clone plasmid constructs by various methods (Digest/ligation, IVA)
• Perform large-scale plasmid preps
• Autoclave glassware and media
• Manage lab inventory and assist in ordering
• Project documentation
• Work with a small team of scientists, while working closely with other research groups and senior managers

Requirements

• Bachelor of Science in Biology or related field
• 3 years of experience in cell biology, molecular biology, immunology, pharmacology or a related field of biology
• Experience in standard cellular and molecular biology techniques (PCR, Digestion, Ligation, Transformation, DNA isolation)
• Experience in standard microbiology techniques (Bacterial cultures, Autoclaving, Preparing Media)
• Demonstrated innovation, creativity and resilience in problem solving
• Excellent oral and written communication skills
• Self-motivated team player with the ability to thrive in a fast paced, multi-disciplinary, matrixed environment

Preferred

• 2 years experience with methods and technologies involving plasmid cloning, AAV packaging, protein expression vectors, microbiology including bacterial cultures and autoclaving
• Experience with Benchling and Snapgene

Wisconsin pay range {{:}} $70,000 USD - $80,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

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