Associate Scientist, CMC Process Development

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Chemist in the Development Chemistry Group focusing on oligonucleotide synthesis development. This is an ideal position for an individual with an organic or biological chemistry background who has an interest in projects related to novel technology in synthesis and purification of oligonucleotides and bioconjugates.

Responsibilities

• Work closely with senior chemists on development of new synthetic approaches to desired compounds with an eye toward large-scale synthesis
• Cooperate with other chemists in the group in preparation of complex organic constructs
• Perform solid-phase synthesis and purification of oligonucleotide drug candidates
• Analyze small-molecule and macromolecular targets using standard methods
• Maintain a well-documented laboratory notebook
• Prepare documentation for transfer of new technologies to the Manufacturing group
• Track progress against project timelines, generate regular status updates, and communicate progress and issues to management, including presentation of findings at team meetings
• Coordinate delivery of materials both internally and externally
  
  

Requirements:

• BS or MS in chemistry or biochemistry with an excellent understanding of organic and analytical chemistry
• Excellent verbal and written communication skills
• Strong problem-solving skills
• Eagerness to learn new techniques
• Experience with synthetic organic chemistry in a laboratory setting
• Experience with small-molecule and macromolecule analytical techniques (e.g., HPLC, UV-Vis spectrophotometry, mass spectrometry, NMR, etc.)
  
  

Preferred:

• Experience working with both small molecule or large molecule synthetic targets either in an academic or industrial setting
• Experience with solid phase synthesis of oligonucleotides or peptides
• Basic familiarity with GLP/GMP regulations
  
  

Wisconsin pay range

$57,000—$70,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

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