Director Medicinal Chemistry

Arnatar Therapeutics is a clinical stage biotechnology company solving critical problems in human health through the discovery and development of innovative medicines. We specialize in targeting RNA for cures across many diseases through a precise RNA medical approach. We are advancing cutting edge antisense technologies to modulate gene expression in a desired way and to discover and develop next generation medicines for large and rare diseases. Our team is comprised of industry leading experts in siRNA and ASO technology who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of RNA targeting drugs that enables rational design and rapid development of antisense medicines to patients with unmet medical needs, while prosecuting a robust pipeline of programs through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment.

Director of Medicinal Chemistry – Nucleic Acids:

Arnatar is seeking a Director of Medicinal Chemistry – Nucleic Acids. This Executive level R&D position requires strategic thinking, an ability to work pro-actively and collaboratively, portfolio mindset and deep scientific expertise across several of the following disciplines: Applicants should have strong experience in oligonucleotide drug synthesis and optimization with a proven track record in delivering clinical candidates. Working as part of a cross-functional team spanning chemistry, biology, analytical sciences, pharmacology, DMPK, and toxicology, the candidate will also manage collaborations and CRO resources as needed. This candidate must have a “can do” attitude with a hands-on approach, being in the lab with direct reports and staff.

Role and responsibilities:

• Lead medicinal chemistry efforts simultaneously on multiple projects from the earliest stages through clinical development
• Ensure the success of chemistry aspects of the drug discovery teams through individual contributions, project leadership, and thorough mentorship of direct reports as emerging chemistry project leaders
• Ensure and execute internal oligonucleotide synthesis activities to support research and drug discovery in a timely manner
• Provide leadership, direction, and contribute to project delivery through motivation, collaborative working, and development of people and line competence within the function
• Demonstrate expertise in drug design and medicinal chemistry strategies to improve drug-likeness, ADME/DMPK, and safety properties
• Develop and execute strategy to protect and expand intellectual property
• Oversee external chemistry CROs as needed
• Collaborate with the executive team to develop a strategy for building and supporting highly innovative platforms

Required qualifications:

• Ph.D. in synthetic organic chemistry or related major with 7 years, MS with 10 years  of pharmaceutical medicinal chemistry in the synthesis or manufacturing of oligonucleotides.
• Experience in the following areas:
• Solid experience in oligonucleotide synthesis is required
• Bioconjugation chemistry is preferred
• Cell delivery technologies is a plus
• Understanding of the IP and regulatory landscape around oligonucleotide therapeutics
• Experience in building robust data packages to support IND filings
• High level of creativity and productivity with strong problem-solving skills, synthetic methods, and reaction mechanisms and analytical methodology
• Extensive experience in program leadership with a demonstrated track record of driving data-based scientific decision-making
• Exceptional interpersonal skills, ability to build and maintain relationships with colleagues at all levels of the organization
•  Demonstrated ability to advance drug discovery programs from biological targets to delivery of development compounds

Preferred Qualifications:

• Desire to work with the team in the lab making novel oligos and developing new processes
• Experience interacting with CMOs for GLPtox batch and GMP synthesis

What we offer:

• Health Benefits
• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Weekly town halls to share business and scientific updates

Arnatar Therapeutics is headquartered in San Diego, California.

Arnatar is an EEOC employer

We do not work with outside recruiters.