Demo

Principal Scientist, Small Molecule Analytical Sciences

Arcus Biosciences
Hayward, CA Full Time
POSTED ON 5/14/2026
AVAILABLE BEFORE 6/19/2026
Description

Summary

W e seek a strong technical problem solver and decision maker to join our analytical team and help us achieve our goals for NDA readiness . This onsite role will be a key contributor to A rcus’ Pharmaceutical Development & Manufacturing organization.

You are a hands-on expert in HPLC method development and mass spectrometry, self-start er and finisher, organized and detail-oriented, and strong verbal and written communicat or . P rior work experience in CMC analytical for new molecular entities in innovator companies , as well as a willingness to own , adapt, and learn , are essential to this role .

Responsibilit ies

  • M ethod development, impurity characterization , experimental design , and testing in Arcus’ well - appo int ed analytical laboratory
  • M anagement of CDMO/CRO testing (release, stability, method validation/transfer)
  • Collaboration with drug substance and drug product development colleagues
  • Documentation (electronic notebooks, authoring technical reports )
  • Opportunities for analytical lead responsibility in CMC teams , regulatory filing authorship, and personnel management, as commensurate with experience and business needs

Qualifications

  • Degree and experience:
    • PhD with 5 years of relevant work experience;
    • or MS with 7 years of relevant work experience;
    • or BS with 9 years of relevant work experience
  • Relevant work experience in CMC analytical development in innovator company that develops new molecular entities ( clinical t o commercial filing phase ), including understanding of cGMPs , phase-appropriate practices, and ICH guidelin es
  • Expertise in HPLC method development , mass spectrometry , and other techniques used in small molecule testing (e.g., GC, dissolution, Karl Fischer)
  • Ability to clearly and effectively elaborate technical concepts in presentations and reports
  • Awareness of timelines and integration of when deliverables need to begin and be completed
This role will be based at our Hayward, CA location. The anticipated salary range for fully qualified candidates applying for this position is $185,000 - $200,000 USD annually. This salary range is an estimate of what we reasonably expect to pay for this posted position. The actual salary may vary based on various factors including, without limitation, individual education, experience, tenure, skills and abilities, internal equity and alignment with market data. In addition to a competitive market-based salary, Arcus offers the opportunity to participate in stock programs, a performance-based bonus, and a comprehensive benefits package. Additional information about our total rewards program can be found here: https://arcusbio.com/careers .

Must possess mobility to work in a standard office setting and use standard office equipment, including a computer; vision to read printed materials and a computer screen; and hearing and speech to communicate in person, before groups, and over the telephone. This is primarily a sedentary office classification although standing in work areas and walking between work areas may be required. Finger dexterity is needed to access, enter, and retrieve data using a computer keyboard, mouse, or calculator, and to operate standard office equipment. Positions in this classification occasionally bend, stoop, kneel, reach, push, and pull drawers open and closed to retrieve and file information. Employees must possess the ability to lift, carry, push, and pull materials and objects weighing up to 25 pounds.

Arcus Biosciences is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Arcus is committed to the principle of equal employment opportunity for all employees and does not discriminate based on race, religion, color, sex, gender identify, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other legally protected status. EOE/AA/Vets

3928 Point Eden Way I Hayward, CA 94545 – Arcus Biosciences is an equal opportunity employer

Salary : $185,000 - $200,000

If your compensation planning software is too rigid to deploy winning incentive strategies, it’s time to find an adaptable solution. Compensation Planning
Enhance your organization's compensation strategy with salary data sets that HR and team managers can use to pay your staff right. Surveys & Data Sets
Employees: Get a Salary Increase
View Core, Job Family, and Industry Job Skills and Competency Data for more than 15,000 Job Titles Skills Library

Job openings at Arcus Biosciences

  • Arcus Biosciences Brisbane, CA
  • At Arcus, the Director, Clinical Pharmacology (CP) functions as the Clinical Pharmacology (CP) team representative at the project teams for small molecule ... more
  • 4 Days Ago

  • Arcus Biosciences Hayward, CA
  • Description At Arcus, the Director, Clinical Pharmacology (CP) functions as the Clinical Pharmacology (CP) team representative at the project teams for sma... more
  • 4 Days Ago

  • Arcus Biosciences Hayward, CA
  • Description Summary The Senior Manager, Biosample Operations will be responsible for planning, implementing, managing, and driving biological sample logist... more
  • 12 Days Ago

  • Arcus Biosciences Brisbane, CA
  • Description Summary The Director , Clinical Operations serves as a core member of the Product Development Team in the role of a Clinical Program Director (... more
  • 14 Days Ago


Not the job you're looking for? Here are some other Principal Scientist, Small Molecule Analytical Sciences jobs in the Hayward, CA area that may be a better fit.

  • Eurofins PSS Insourcing Solutions Berkeley, CA
  • Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industrie... more
  • 4 Days Ago

  • Merck Oakland, CA
  • Job Description Global Quality Large Molecule Analytical Sciences (GQ- LMAS), in our Manufacturing Division, is accountable for the commercialization of la... more
  • 6 Days Ago

AI Assistant is available now!

Feel free to start your new journey!