What are the responsibilities and job description for the Scientist, Immuno-Oncology and Immunology position at Apeximmune Therapeutics?
Company Overview
Apeximmune Therapeutics is a preclinical-stage biotechnology company harnessing the power of the immune system to develop transformative therapies for cancer and autoimmune diseases. Based in South San Francisco, we integrate expertise in immunology, tumor biology, autoimmune diseases, and protein engineering to discover and advance next-generation antibody therapeutics. Our pipeline includes several antibody assets in preclinical development, with plans to submit our INDs in 2026-2027.
The Role
Apeximmune is seeking a talented and motivated Scientist with a strong background in cellular and molecular immunology and cancer biology to join our therapeutic antibody discovery team. This position will lead bi-specific antibody projects towards clinical candidate development.
This is a high-impact role in which, you will be responsible for all aspects of the project including strategic design, daily bench-level execution, direct supervision and mentorship to Scientific Research Associates (SRAs). Your work and leadership will be a key component of Apeximmune’s strategic goals.
Key Responsibilities
- Independently lead bispecific antibody projects, including strategic planning and defining the path toward therapeutic products.
- Lead from the bench by developing and optimizing binding and cell-based functional assays for hybridoma screening.
- Supervise, train, and manage SRAs to ensure high-quality data generation and professional growth within the team.
- Run complex experiments, perform rigorous troubleshooting, and analyze results to identify and characterize lead candidates.
- Execute and manage contract research organization (CRO) conducting hybridoma generation campaigns
- Manage in vivo preclinical studies and provide hands-on support to SRA and/or technicians as needed to ensure successful outcome.
- Apply advanced analytical skills to overcome technical hurdles and optimize protocols for lead candidate identification.
- Actively collaborate within the team, contributing to other ongoing projects and sharing your expertise to foster a learning environment.
- Participate in and present data at internal meetings, ensuring clear documentation of all findings.
- Keep up-to-date with current scientific literature to help identify new targets or new strategies for existing targets.
Requirements
- Ph.D. in immunology, cell biology, oncology, or a related scientific field with 3 years of postdoctoral or equivalent industry experience.
- Extensive hands-on experience with basic tissue culture of mammalian cell lines and primary cells.
- Proven expertise in the development and troubleshooting of cell-based functional in vitro immunoassays (e.g. ELISA, MSA).
- Proficiency in the isolation and characterization of human and mouse primary immune cells.
- Mastery of multi-color flow cytometry is a must, alongside a deep knowledge of FACS-based phenotypic and functional characterization of immune cell populations.
- Experience in syngeneic and/or transgenic mouse tumor/autoimmune models is highly desirable
- Proficiency with data analysis software including GraphPad Prism and Excel.
- Excellent written and oral communication, organization, and presentation skills.
- Strong critical thinking, excellent problem-solving, and meticulous documentation skills.
- Flexibility and enthusiasm for working in a fast-paced, innovative startup environment.
Why Join Apeximmune?
If you are excited about creating therapies that can make a real difference for patients, enjoy working in a collaborative and fast-growing team, and want an opportunity to expand your scientific and professional horizons—we’d love to hear from you.
To Apply: Send your resume to careers@apeximmune.com.