Postdoctoral Researcher

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Company Description: Antigenix Therapeutics is an early-stage drug discovery company with a clear goal: give cancer patients more hope and more choices by advancing next generation, antibody-based precision oncology. Headquartered in Princeton, NJ, the company is developing patented antibody-based therapies that precisely target cancer cells and push the boundaries of what is possible in cancer treatment. Additional information about the company can be found at www.antigenixthera.com.

Position: Postdoctoral Research Scientist

Location: Princeton, NJ (in-person)

Team: Research

Type: Full-Time

Job description

We are looking for a recent Ph.D. graduate or a current postdoctoral scientist who is interested in exploring the biology of a proprietary novel cell surface target and its role in various cancers including triple negative breast cancer (TNBC), non-small cell lung cancer (NSCLC), castration resistant metastatic prostate cancer, pancreatic cancer and other tumor types. The candidate would assist in the evaluation of biologics targeting this novel target.

• This position is supported by grant funding intended to advance technological and scientific research in New Jersey.
• The role is designed for recent Ph.D. graduates and late-stage Ph.D. candidates to continue their research in and gain industry exposure at a NJ Based Biotech startup
• The position will be primarily research-focused, supporting innovation and scientific advancement.
• Grant funding may include limited support for research-related expenses, such as equipment or conference attendance, in accordance with grant guidelines.

The Role

You will assist in developing biologics, including antibody drug conjugates (ADCs), bispecific ADCs and bispecific T-cell engagers (BiTes), against a novel ADC target. Responsibilities include:

1. Evaluating the expression of this ADC target and related targets in a panel of human tumor cell lines and in human tumor xenograft models.
2. Developing stable knockout cell lines that no longer expresses the target protein(s).
3. Developing luciferase expressing tumor cell lines and establish tumor xenograft models.
4. Developing human tumor cell lines that are resistant to common payloads used for ADCs and identify mechanisms of resistance that are also found in cancer patients.
5. Establishing in vitro assays, including cytotoxicity assays, to evaluate the biologics.
6. Publishing in high impact peer reviewed journals and present at international meetings.

What your day will look like

• Conduct independent and collaborative research aligned with the company’s scientific objectives.
• Design, execute, and analyze experiments or studies related to the assigned research area.
• Make timely entries into the company’s electronic notebook.
• Document research findings and contribute to internal reports, presentations, or publications.
• Collaborate with internal scientific and technical teams to advance research milestones.
• Support grant reporting requirements as needed.

What you should possess

1. Expertise in molecular biology techniques to produce knockout constructs and expression constructs.
2. Expertise in mammalian cell culture to establish stable recombinant cell lines.
3. Knowledge of using multi-color flow cytometry to identify specific cell surface markers.
4. Experience performing in vitro assays, such as cytotoxicity assays using cell-titer glo or Alamar blue.
5. Willingness to learn how to clone, express and purify proteins such as recombinant monospecific and bispecific antibodies.
6. Strong work ethic and able to work collaboratively under minimal supervision.
7. Excellent written and verbal communication in English.
8. Graduated from doctoral program after January 2026 or will graduate before January 2027
9. New Jersey Resident
10. US citizenship or EAD

Additional desired experience

1. Expertise in biochemistry
2. Graduated from NJ university
3. Interest in working in a dynamic start up environment
4. Experience working with CRISPR or FACS

While you will be working in the Princeton BioLabs conveniently located off of route 1, there will also be occasional travel for trade conferences and educational development. This will be a great opportunity to use your education by creating and commercializing a novel product that makes a difference. If you are excited finding ways to give cancer patients more hope and more choices, definitely apply.