Physician Principal Investigator (Clinical Research)

Build the Future of Clinical Research

Are you a physician interested in expanding your career into clinical research while maintaining the flexibility of your current medical practice?

We are establishing a new independent clinical research site in New Caney, Texas, and are seeking a qualified and motivated physician to serve as a Principal Investigator (PI) for Phase II–IV clinical trials.

This is an opportunity to become one of the founding physicians helping build a high-quality research program while advancing innovative therapies for patients throughout Northeast Houston. You will work alongside an experienced Senior Clinical Research Coordinator and research operations team in building a site committed to scientific excellence, patient safety, and regulatory compliance.

Whether you are an experienced Principal Investigator or a physician looking to expand into clinical research, we encourage you to apply.

Why Join Us?

• Flexible part-time schedule designed to complement your current medical practice.
• Competitive hourly compensation.
• Become one of the founding physicians helping establish a new independent clinical research site.
• Long-term leadership opportunity within a growing clinical research organization.
• Collaborate with an experienced clinical research operations team.
• Expand your professional career into clinical research while maintaining flexibility.
• Participate in innovative clinical research that brings new therapies to patients throughout Northeast Houston.
• Opportunity for increased responsibilities and compensation as the research program continues to grow.

Ideal Candidate

We are looking for physicians who:

• Are passionate about advancing medical science.
• Enjoy collaborating with multidisciplinary healthcare teams.
• Value ethical, patient-centered care.
• Have strong clinical judgment and leadership skills.
• Are interested in helping build a successful independent clinical research program from the ground up.

Key Responsibilities

• Serve as Principal Investigator for Phase II–IV clinical research studies.
• Provide medical and scientific oversight for assigned clinical trials.
• Protect participant safety while ensuring ethical and compliant research conduct.
• Review study protocols and participate in feasibility assessments.
• Evaluate participant eligibility and provide clinical oversight throughout each study.
• Work closely with the Senior Clinical Research Coordinator and research staff.
• Participate in Sponsor and CRO qualification calls, meetings, and site visits.
• Participate in Site Qualification Visits (SQVs), Site Initiation Visits (SIVs), and Monitoring Visits.
• Review adverse events, serious adverse events, laboratory results, ECGs, and other clinically significant findings.
• Review and sign required medical and regulatory documentation.
• Supervise delegated study activities while maintaining appropriate physician oversight.
• Participate in investigator meetings and protocol-specific training.
• Ensure compliance with FDA regulations, ICH-GCP guidelines, study protocols, and sponsor requirements.
• Help shape the long-term growth and strategic direction of the research site.
• Build strong professional relationships with Sponsors, CROs, CRAs, and research partners.

Required Qualifications

• MD or DO degree.
• Active and unrestricted Texas Medical License.
• Good professional standing.
• Strong clinical judgment and communication skills.
• Ability to exercise independent medical judgment while providing appropriate oversight of research participants.
• Ability to collaborate effectively with CRCs, Sponsors, CROs, CRAs, and research staff.
• Willingness to complete Good Clinical Practice (GCP) and protocol-specific training if needed.
• Ability to travel to the New Caney research site as required.

Preferred Qualifications

• Previous experience as a Principal Investigator or Sub-Investigator preferred, but not required.
• Previous participation in Phase II, III, or IV clinical trials.
• Current active clinical practice.
• Established patient population or physician referral network is highly desirable.
• Experience with Sponsor/CRO interactions, feasibility assessments, Site Qualification Visits (SQVs), Site Initiation Visits (SIVs), Monitoring Visits, and regulatory compliance.
• Interest in helping build and grow an independent clinical research organization.

Preferred Specialties

We encourage applications from physicians in:

• Family Medicine
• Internal Medicine
• Endocrinology
• Cardiology
• Gastroenterology
• Pulmonology
• Neurology
• Psychiatry
• Women's Health / OB-GYN
• Dermatology
• Rheumatology
• Infectious Disease
• Nephrology
• Pain Management

Physicians from other specialties with an interest in clinical research are also encouraged to apply.

Schedule & Work Model

This is a flexible part-time contract opportunity designed to accommodate an active medical practice.

Physician involvement will vary based on study activity, enrollment, and protocol requirements. On-site availability in New Caney, Texas is required for activities requiring physician oversight. Administrative tasks, investigator meetings, protocol training, and document reviews may be completed remotely when permitted by sponsor and protocol requirements.

Compensation

$150.00 – $250.00 per hour

Compensation will be determined based on medical specialty, previous Principal Investigator or Sub-Investigator experience, clinical research background, availability, and overall level of involvement within the organization.

Additional opportunities for expanded responsibilities and increased compensation may become available as the research program grows.

About the Opportunity

This position is ideal for physicians who want to expand their involvement in clinical research while maintaining flexibility in their current medical practice.

As one of our Founding Principal Investigators, you will play a key role in establishing a high-quality independent clinical research site dedicated to advancing medical innovation and improving patient care.

We are committed to building long-term relationships with physicians who are passionate about research, collaboration, and professional growth.

Previous Principal Investigator experience is preferred but not required. Physicians with strong clinical experience, an active Texas Medical License, and a genuine interest in clinical research are encouraged to apply. Research training and ongoing support will be provided when appropriate.

Our mission is to expand patient access to innovative therapies while delivering exceptional patient care, scientific integrity, and operational excellence. We are seeking physicians who share this vision and are excited to help shape the future of our organization.

Join Our Founding Team

If you are looking for an opportunity to expand your medical career, participate in cutting-edge clinical research, and help establish a high-quality independent research site serving Northeast Houston, we would love to hear from you.

Become one of the founding physicians helping shape the future of our organization.

Apply today and join us in advancing the future of clinical research.

Pay: $150.00 - $250.00 per hour

Benefits:

• Flexible schedule
• Free parking
• Professional development assistance

Work Location: Hybrid remote in New Caney, TX 77357

Salary : $150 - $250