Senior Director, HRBP - Commercial

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

Reporting to the SVP, Human Resources and Talent Acquisition, the Senior Director, HR Business Partner (HRBP) for the Commercial Organization is a strategic leadership role responsible for partnering closely with the Chief Commercial Officer (CCO) and Commercial Leadership Team to build, scale, and optimize a high-performing commercial function. This individual will serve as a trusted advisor, aligning people strategies with business objectives to support the successful transition to and execution of commercialization, including both corporate and field-based teams.

This role will be hired in advance of commercial scale-up and top-line data, within a lean and evolving organization. While the primary focus is supporting the Commercial function, the Senior Director will initially operate as a broad HR Business Partner across the enterprise, flexing support across Clinical, Technical Operations, and G&A as needed. This role requires comfort operating in a highly dynamic, resource-constrained environment, with the ability to balance strategic leadership with hands-on execution.

As the organization evolves through key clinical and commercial milestones, this role is expected to scale in scope and impact, transitioning from a broad, hands-on HR Business Partner role to a more dedicated commercial HR leadership position.

Responsibilities

Strategic Partnership & Leadership

• Serve as the primary HR partner to the CCO and Commercial Leadership Team, providing strategic counsel on organizational effectiveness, talent, and culture
• Contribute to the development and execution of the commercial strategy by aligning HR initiatives with business priorities
• Act as a thought partner on scaling the organization from pre-commercial to fully commercial operations
  
  
  

Organizational Design & Build-Out

• Lead the design and implementation of the commercial organizational structure, including headquarters and field-based teams (e.g., sales, market access, patient services, marketing)
• Support workforce planning aligned to launch readiness, market expansion, and long-term growth
• Drive role clarity, spans and layers optimization, and organizational efficiency
  
  
  

Talent Strategy & Development

• Partner with leadership to attract, retain, and develop top commercial talent, including building leadership capability across the organization
• Guide succession planning and leadership development initiatives
• Coach senior leaders on performance management, team effectiveness, and change leadership
  
  
  

Performance & Compensation

• Collaborate with Total Rewards to design and implement competitive compensation and incentive programs aligned with commercial goals (including sales incentives and LTI structures)
• Support performance management processes aligned to corporate and commercial objectives, ensuring the foundational elements of a high-performing commercial culture are in place, including clear goal-setting, accountability, and differentiated performance outcomes
  
  
  

Culture & Employee Experience

• Champion a high-performance, patient-centric culture aligned with company values
• Lead change management initiatives to support rapid growth and evolving business needs
• Ensure strong employee engagement across both corporate and geographically dispersed field teams
  
  
  

Employee Relations & Compliance

• Provide guidance on complex employee relations matters with sound judgment and business alignment
• Ensure compliance with all applicable employment laws and company policies, particularly within a distributed field organization
  
  
  

Required Qualifications

• Bachelor’s degree in Human Resources, Business Administration, or related field required; Master’s degree (MBA, MS, or equivalent) strongly preferred
• Minimum of 15 years of progressive HR experience, including significant HR Business Partner leadership roles
• Demonstrated experience partnering with a Chief Commercial Officer and senior commercial leadership in building and scaling commercial organizations while being willing to operate beyond a single function and support enterprise-wide needs
• Proven success supporting both corporate and field-based teams, including sales organizations
• Experience within biotechnology or pharmaceutical industry required; rare disease experience strongly preferred
• Comfortable navigating ambiguity and shifting priorities, with a willingness to take on both strategic and hands-on HR responsibilities across multiple functions
• Deep expertise in organizational design, talent management, and change leadership in high-growth environments
• Strong business acumen with the ability to translate strategy into actionable HR initiatives
  
  
  

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis. Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis.
• When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.
  
  
  

Compensation

The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.

Estimated Pay Range

$243,000 - $273,000 USD

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Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.