Demo

Principal Software Engineer

Amgen and Careers
Thousand Oaks, CA Full Time
POSTED ON 6/28/2026
AVAILABLE BEFORE 7/28/2026
US - Florida - Tampa
JOB ID: R-240841 LOCATION: US - Florida - Tampa ; US - California - Thousand Oaks WORK LOCATION TYPE: Flex Commuter / Hybrid DATE POSTED: Apr. 20, 2026 CATEGORY: Information Systems SALARY RANGE: 157,020.50USD -212,439.50 USD

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Software Engineer

What you will do

Let’s do this. Let’s change the world. In this vital role you will play a pivotal role in shaping our technology strategy and mentoring a team of talented engineers.

Roles & Responsibilities:

  • Possesses strong rapid prototyping skills and can quickly translate concepts into working code

  • Provide technical guidance and mentorship to the development team.

  • Take ownership of complex software projects from conception to deployment.Manage software delivery scope, risk, and timeline

  • Contribute to both front-end and back-end developmentusing cloud technology.

  • Develop innovative solution using generative AI technologies

  • Define and implement robust software architecturesonthecloud, AWS preferred

  • Lead and motivate a team of engineers to deliver high-quality results.

  • Conduct code reviews to ensure code quality and adherence to best practices.

  • Create and maintain documentation on software architecture, design, deployment, disaster recovery, and operations.

  • Identify and resolve technical challenges effectively.

  • Stay updated with the latest trends and advancements

  • Work closely with productteam, business team, and other stakeholders.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Software engineer with these qualifications.

Basic Qualifications:

Doctorate degree and 2 years of experience
OR
Master’s degree and 4 years of experience
OR
Bachelor’s degree and 6 years of experience
OR
Associate’s degree and 10 years of experience
OR
High school diploma / GED and 12 years of experience

  • Hands on experience with various cloud services, understand pros and cons of various cloud service inwellarchitected clouddesignprinciples

  • Hands on experience with Full Stack software development. Proficient in programming language Python(preferred), JavaScript, SQL/NoSQL.

  • Proven ability to lead and mentor software development teams

  • Strong problem solving,analytical skills; Ability to learn quickly; Excellent communication and interpersonal skills

  • Strong presentation and public speaking skills.

Preferred Qualifications:

  • Experienced with API integration, serverless, microservices architecture.

  • Experience in SQL/NOSQL database, vector database for large language models

  • Experience with popular large language models

  • Experience withLangchainorllamaIndexframework for language models

  • Experience with prompt engineering, model fine tuning

  • Experience with Web site development, understand of web site localization processes, which involve adapting content to fit cultural and linguistic contexts.

  • Experience with DevOps/MLOpsCICD build and deployment pipeline

  • Experience with design patterns, data structures, test-driven development.

  • Knowledge of NLP techniques for text analysis and sentiment analysis

Bachelor’s degree in computer science and engineering preferred, otherEngineering field is considered;Master’sdegree and 6 years of software development experienceOrBachelor’s degree and 8 years of software development experience

  • Cloud Computing certificate preferred

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Salary : $157,021 - $212,440

If your compensation planning software is too rigid to deploy winning incentive strategies, it’s time to find an adaptable solution. Compensation Planning
Enhance your organization's compensation strategy with salary data sets that HR and team managers can use to pay your staff right. Surveys & Data Sets

What is the career path for a Principal Software Engineer?

Sign up to receive alerts about other jobs on the Principal Software Engineer career path by checking the boxes next to the positions that interest you.
Income Estimation: 
$176,149 - $220,529
Income Estimation: 
$156,679 - $196,968
Income Estimation: 
$91,370 - $117,201
Income Estimation: 
$115,390 - $147,559
Income Estimation: 
$106,780 - $140,358
Income Estimation: 
$104,963 - $131,876
Employees: Get a Salary Increase
View Core, Job Family, and Industry Job Skills and Competency Data for more than 15,000 Job Titles Skills Library

Job openings at Amgen and Careers

  • Amgen and Careers Grand Rapids, MI
  • US - Michigan - Grand Rapids JOB ID: R-242132 LOCATION: US - Michigan - Grand Rapids WORK LOCATION TYPE: Field Worker DATE POSTED: Apr. 15, 2026 CATEGORY: ... more
  • 1 Day Ago

  • Amgen and Careers Thousand Oaks, CA
  • US - California - Thousand Oaks JOB ID: R-239806 LOCATION: US - California - Thousand Oaks WORK LOCATION TYPE: Flex Commuter / Hybrid DATE POSTED: Apr. 23,... more
  • 1 Day Ago

  • Amgen and Careers Kansas, MO
  • US - Colorado - Denver JOB ID: R-245394 LOCATION: US - Colorado - Denver ; US - Wyoming - Cheyenne; US - Montana - Billings; US - South Dakota - Sioux Fall... more
  • 2 Days Ago

  • Amgen and Careers Springs, NC
  • US - North Carolina - Holly Springs JOB ID: R-246224 LOCATION: US - North Carolina - Holly Springs WORK LOCATION TYPE: On Site DATE POSTED: Jun. 01, 2026 C... more
  • 3 Days Ago


Not the job you're looking for? Here are some other Principal Software Engineer jobs in the Thousand Oaks, CA area that may be a better fit.

  • Judge Group, Inc. Moorpark, CA
  • Location: Moorpark, CA Salary: $180,000.00 USD Annually - $198,000.00 USD Annually Description: The Judge Group is currently seeking a Principal Software E... more
  • 5 Days Ago

  • The Guitar Center Company Westlake Village, CA
  • JOB SUMMARY: We are seeking a highly experienced Principal Software Engineer to lead the evolution of our enterprise service capabilities. In this role, yo... more
  • 1 Month Ago

AI Assistant is available now!

Feel free to start your new journey!