Senior Medical Director, US Medical Affairs - TTR

Overview

The Senior Medical Director, US Medical Affairs – TTR is accountable for leading the end-to-end US evidence generation strategy and execution in close partnership with Global Medical Affairs. This role drives the development of high-impact, non-promotional evidence to support clinical understanding, inform treatment decisions, and improve patient outcomes in transthyretin (TTR) amyloidosis.

This individual will oversee US-based Investigator-Sponsored Studies (IIS/IIT), real-world evidence (RWE) initiatives, and serve as the US medical lead for publications, ensuring strong US input and execution within the global publications framework. The role includes direct management of an Associate Director and leadership across key enterprise evidence initiatives, including VEST and Health Systems evidence generation.

Key Responsibilities

End-to-End US Evidence Generation Leadership

• Own and lead the end-to-end US evidence generation strategy and execution, aligned with global medical and enterprise priorities
• Identify and prioritize US-specific evidence gaps and translate them into actionable study plans
• Drive development and execution of RWE, observational studies, registries, and database analyses (e.g., EHR, claims)
• Ensure seamless execution across the study lifecycle: concept development, protocol design, governance, execution, analysis, and dissemination
• Deliver high-quality, timely, and impactful evidence to support clinical practice and patient outcomes

Health Systems Evidence Generation Leadership

• Serve as the US medical lead for Health Systems evidence generation strategy and execution
• Develop and advance evidence to demonstrate value in real-world clinical practice, including outcomes, healthcare utilization, and system-level impact
• Partner cross-functionally (e.g., HEOR, Market Access, Commercial, Global Medical) to align on priorities and maximize evidence impact
• Ensure integration of health systems evidence into broader US and global evidence strategies

Investigator-Sponsored Studies (IIS/IIT) Oversight

• Provide strategic and scientific oversight of the US IIS/IIT portfolio
• Lead evaluation, prioritization, and governance of IIS proposals aligned with medical strategy
• Partner with investigators to shape robust, hypothesis-driven research
• Ensure compliance with internal policies, regulatory requirements, and ethical standards

Publications (US Medical Lead)

• Serve as the US Medical Affairs lead for publications, ensuring strong US input into global publication strategy
• Partner with Global Medical Affairs to align on publication priorities, timelines, and execution
• Lead execution of US-led publications (abstracts, posters, manuscripts) in alignment with global plans
• Provide medical review to ensure scientific accuracy, relevance, and compliance
• Collaborate cross-functionally to ensure appropriate integration of clinical, RWE, and HEOR data

VEST Leadership

• Serve as the primary US Medical lead to the VEST team, representing US medical priorities and ensuring alignment with enterprise evidence strategy
• Provide strategic input into VEST initiatives and ensure execution of US evidence components
• Act as a key connector between US Medical and cross-functional stakeholders involved in VEST

People Leadership

• Directly manage and develop one Associate Director
• Provide clear direction, prioritization, and coaching to ensure high performance and professional growth
• Foster a culture of accountability, collaboration, and scientific excellence

Cross-Functional Leadership

• Serve as a key medical partner across US and Global Medical Affairs, Clinical Development, HEOR, Market Access, and Commercial teams
• Translate complex data into clear, actionable insights for internal stakeholders
• Support field medical teams with evidence strategy and emerging insights
• Contribute to lifecycle management and differentiation through evidence generation

External Engagement

• Build and maintain relationships with key opinion leaders (KOLs), academic institutions, and research networks
• Support strategic research collaborations aligned with US evidence priorities
• Represent the organization at scientific meetings and investigator interactions

Qualifications

Education & Experience

• MD, PharmD, or PhD in a relevant scientific or clinical discipline
• 8–12 years of experience in Medical Affairs, Clinical Development, or related functions
• Demonstrated experience leading evidence generation (RWE, IIS/IIT) and supporting publications
• Prior people management experience preferred
• Experience in rare disease, cardiovascular, or related therapeutic areas preferred

Skills & Capabilities

• Strong ownership mindset with ability to lead end-to-end strategy and execution
• Deep understanding of RWE methodologies, study design, and health systems evidence
• Proven ability to lead cross-functional initiatives in a matrixed, global environment
• Strong communication and executive presence
• High integrity and commitment to compliance and scientific excellence

Leadership Expectations

• Enterprise thinker with strong ownership and accountability
• Balances strategic vision with disciplined execution
• Builds and develops talent
• Trusted scientific leader internally and externally

U.S. Pay Range

$266,800.00 - $361,000.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.