Demo

Senior Manager Program Management

Alnylam Pharmaceuticals
Cambridge, MA Full Time
POSTED ON 1/10/2026
AVAILABLE BEFORE 2/8/2026

Overview


At Alnylam, clinical-stage development programs are managed by a Global Program Leadership Team, led by a Program Leader and a Program Manager, responsible for harnessing cross-functional expertise to define the best scientific, clinical, and commercial strategies and plans for the success of the Program.


The role of the Senior Manager, Program Management is to partner with Program Leaders of the portfolio to drive program strategy and execution of various assets in the development portfolio. The candidate will be responsible for providing a combination of drug development stewardship and program expertise to the Program Leadership Teams. This role, through partnership with Program Leaders, has significant responsibility for developing, driving, operationalizing, and executing the program strategy. In this role, the candidate will be required to work closely with development stage appropriate sub-teams for each program such as Nonclinical Subteam, Clinical Development Sub-teams (CDST), the CMC Sub-team, and Early Commercial and Medical Strategy team (ECoMS), as part of the overall Program Leadership Team.


The candidate will also be responsible for driving the identification/implementation of Program Management best practices within Alnylam. In this capacity, the candidate will call upon prior experience and program management insights to continually help the program management team increase its efficiency and value.


This position is hybrid and will be primarily located in Cambridge, MA.


Summary of Key Responsibilities


  • Partner closely with Program Leaders to shape and execute the Program strategy, goals and plans and ensure alignment within the Program Team and across all expertise areas.
  • Lead development and drive execution of Program workplans/timelines and integrated development plans with milestones/goals, key events, risks/assumptions, and scenarios.
  • Lead high-performing teams while driving coordination of cross-functional activities and promote effective communications (e.g., Team meetings, program updates); integration of people involved within the program (e.g. clarity of responsibilities).
  • In partnership with the Program Leader, ensure clear, timely, and substantive updates on Program progress and issues to Senior Leadership.
  • Manage Program Leadership Team meetings, including leading discussions to drive to decision-making, agenda creation, meeting minutes, and actions.
  • Serve as a key point person for Leadership Team members and governance teams.
  • Owner of key program documents, e.g., integrated development plan, risk plan, and additional key status and timeline updates, ensure team members have easy access to program information.
  • Partner with finance on all financial aspects of the Program.
  • Provide insights on program management initiatives including alignment of processes, tools, and technologies that aid in portfolio management across the organization.


Qualifications


  • Bachelor’s degree or higher-level education in sciences or related field required. Advanced degree in a scientific discipline preferred.
  • Minimum of 3-5 years experience in biotechnology or pharmaceutical industry with an in depth knowledge of drug development demonstrated experience working with and managing cross-functional program teams
  • Direct drug development program management experience, with ability to work in early and/or late-stage clinical programs.
  • Demonstrated ability to work proactively, both independently and collaboratively, in a dynamic team environment, set priorities and drive to results; ability to integrate multiple viewpoints and build alignment
  • Ability to understand interdependencies and critical path across drug development
  • Excellent written and oral communication, including presentation, facilitation skills and a strong presence when speaking.
  • Strong analytical and problem-solving skills; ability to combine attention to detail within broader strategic context.
  • Superior collaboration and negotiation skills, and high degree of self-awareness.
  • Ability to thrive in a fast-paced environment with strong ability to simultaneously handle multiple activities, with agility and adaptability.
  • Proficiency with program/project management tools such as PowerPoint, Word, Excel, and/or Smartsheets or similar.
  • Passion for helping patients and developing transformative treatments for patients in need; motivated by patient focus and personal commitment to high performance and results.

Salary.com Estimation for Senior Manager Program Management in Cambridge, MA
$182,173 to $229,604
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