Director, New Product Commercialization, Next Wave

We are seeking a strategic and analytically rigorous Director, New Product Commercialization, Next Wave, to lead the evaluation of commercial potential for our early-stage pipeline assets. This role sits at the intersection of R&D and commercial strategy and will play a pivotal role in shaping portfolio priorities, guiding clinical development strategies, and maximizing the long-term value of our drug candidates.

Key Responsibilities

Drug Candidate Asset Evaluation

• • Conduct drug candidate asset and indication evaluations -- lead development of preliminary TPPs and differentiation hypothesis with cross functional team
  • Evaluate market opportunity, unmet need, patient segmentation, and treatment paradigms
  • Translate clinical data into clear commercial implications and strategic recommendations
  • Identify key value drivers, risks, and "make-or-break" assumptions for each asset

Market & Competitive Intelligence

• • Conduct deep competitive landscape assessments, including pipeline tracking and benchmarking
  • Monitor evolving standard of care, pricing dynamics, and access considerations across key markets
  • Synthesize primary and secondary market research into actionable insights

Evidence & Development Strategy Input

• • Provide commercial input into clinical trial design (endpoints, comparators, patient populations)
  • Identify evidence gaps required to support future pricing, reimbursement, and differentiation
  • Ensure alignment between clinical development plans and future market access needs

Lead without formal authority

• • Manage external partners that support asset evaluation; serve as conduit between internal program teams and analytic partners
  • Comfortable building from scratch (frameworks, models, narratives)
  • Act as a key commercial voice within cross-functional asset teams
  • Influence senior stakeholders and executive leadership with clear, data-driven recommendations

Qualifications

• Bachelor's degree required; advanced degree preferred (MBA, PhD, PharmD, or MD)
• 10 years of experience in biotech/pharma, with a strong focus on commercial strategy, new product planning, or consulting
• Demonstrated experience supporting drug development decisions (preclinical through Phase 3)
• Strong strategic thinking and ability to connect clinical data to commercial outcomes
• Deep understanding of drug development, market access, and healthcare ecosystems
• Advanced analytical and financial modeling skills (forecasting, valuation)
• Excellent communication and storytelling skills, with the ability to influence senior leaders
• Experience working in cross-functional, matrixed environments
• Highly collaborative with strong stakeholder management skills
• Comfortable with ambiguity and able to operate in early-stage environments
• Action-oriented with a strong sense of ownership and accountability
• Curious, insightful, and driven by impact

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U.S. Pay Range

$208,300.00 - $281,800.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.