Senior Research Associate – Scientist II, Molecular Biology & Viral Vector Platforms

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Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CARs), to facilitate durable activity in patients. For more information, please visit our website at https://www.adicetbio.com.

Senior Research Associate – Scientist II, Molecular Biology & Viral Vector Platforms

Contract Duration: One year

Why this matters:

This role accelerates cell and genome therapy research by enabling reliable generation, characterization, and improvement of lentiviral vectors used in discovery and preclinical studies.

The Opportunity

We are seeking a highly motivated Senior Research Associate / Associate Scientist (BS/MS) to advance lentiviral vector research with some early process development. This is a 100% bench-based, hands-on laboratory role focused on running, troubleshooting, and improving upstream and downstream LVV workflows to enable discovery and preclinical studies.

Hands-on, bench role: This position is primarily lab-based and focuses on molecular biology, library design/generation for screening mammalian/phage display or related, lentiviral vector production, and T cell / immune cell workflows. Success in this role requires strong experimental execution, troubleshooting, and clear ELN documentation.

Key Responsibilities

• Design, build, and QC DNA constructs and variant libraries for screening (e.g., mammalian/phage display), including cloning strategy and library design influenced by structure-function analysis.
• Produce, titer, and QC lentivirus from HEK293T or derivatives; optimize transfection and harvest conditions to improve yield/quality.
• Perform mammalian tissue culture (maintenance, banking, transfection/transduction) in BSL-2; support scale-up as needed (cell factories and/or single-use bioreactors, where applicable).
• Execute immune cell workflows as applicable (PBMC/T cell isolation, activation, gene delivery, expansion) and support functional characterization.
• Run qPCR/RT-qPCR and multi-parameter flow cytometry; analyze results, troubleshoot, and recommend next experiments.
• Maintain rigorous ELN documentation and follow EHS/BSL-2 practices for viral vectors and human-derived materials.

Leveling will align with experience （Senior Research Associate through Scientist)and demonstrated hands-on capability in molecular biology, library generation/screening, lentivirus, and cell culture/immune cell workflows.

Qualifications

Minimum Qualifications

• B.S. 4 years, M.S. 2 years, or Ph.D. 1–2 years （or equivalent） in Molecular Biology, Cell Biology, Immunology, Bioengineering, Biochemistry, or related field.
• Strong molecular cloning and nucleic-acid workflows (vector design, Gibson/In-Fusion, plasmid prep, PCR/qPCR) with independent troubleshooting.
• Library design/build for screening or display (mammalian/phage or related) and support of selection/screen workflows.
• Lentivirus production in HEK293T/293T (transfection, harvest) plus titering/QC (qPCR/ddPCR, p24, and/or functional assays).
• Strong mammalian tissue culture (aseptic technique, expansion, banking) and comfort in BSL-2.
• High experimental rigor, clear ELN documentation, and ability to run multiple experiments in parallel.

Preferred Qualifications

• T cell activation, lentiviral transduction, expansion, and flow cytometry-based phenotyping/functional readouts.
• NGS-enabled library readouts (barcoding strategies, sample prep coordination, and basic analysis partnership).
• Viral vector scale-up/scale-down (cell factories, wave, or single-use bioreactors) and/or downstream handling (clarification/filtration, UF/DF, TFF

*This role is open to individual contractors only. Recruitment agencies: please do not contact us or submit candidates.

Adicet fosters a collaborative, high-performing environment by prioritizing in-person engagement. To enhance teamwork and communication, employees are required to be onsite at least three days per week (Tuesday–Thursday mandatory), with some roles requiring full-time onsite presence.

At Adicet, our people are our greatest focus. We believe that attracting and retaining the best and brightest is the key to achieving our mission to deliver best-in-class gamma delta T cell therapies for patients fighting autoimmune diseases and cancer. 

We offer a competitive compensation package including base salary, annual cash bonus, long-term incentives (equity), Employee Stock Purchase Plan (ESPP) and a 401(k) with ROTH and a 4.5% Company match. 

To ensure the wellness of our employees and their loved ones, we offer comprehensive health plans (medical, dental, vision, etc.), Flexible Health and Commuter Spending Accounts (FSA) and a company matched Health Savings Account (HSA). We also offer a life, AD&D, short and long-term disability insurance, and legal, pet, and various other voluntary insurance programs. 

We also believe our greatest ideas come when we are refreshed and focused, and we offer generous paid time-off including 13 company holidays, paid end-of-year winter break, vacation, sick time, and paid parental leave. 

Adicet is located in a state-of-the-art facility and works to create an incredible office experience with an onsite gym and various other fitness options, onsite parking with electric vehicle charging stations and free shuttle (Caltrain), company-subsidized lunches (delivered onsite daily) and fully stocked breakrooms. 

Adicet is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.