What are the responsibilities and job description for the Principal Scientist/Director, Translational Pharmacology position at 5AM Ventures?
We are seeking a highly motivated, hands-on Director of Translational Pharmacology to lead and drive preclinical pharmacology efforts across our pipeline. This individual will play a central, decision-making role in translating innovative science into rigorous, in vivo proof-of-concept and clinically actionable pharmacology strategies.
\n- Lead the design, execution, and interpretation of preclinical pharmacology studies supporting drug discovery and development programs
- Develop and apply quantitative PK/PD models, integrating pharmacokinetics, pharmacodynamics, and chemical kinetics to guide compound optimization and dosing strategies
- Design and oversee in vivo studies, including selection and development of appropriate animal models
- Drive rigorous data analysis, including statistical evaluation and modeling to inform decision-making
- Translate preclinical findings into clinically relevant hypotheses and development strategies
- Collaborate closely with teams to optimize drug candidates and delivery systems
- Contribute to regulatory documentation and strategy (IND-enabling studies, study reports, etc.)
- Build and manage relationships with CROs and external collaborators
- PhD, MD, or equivalent in pharmacology, biomedical sciences, or related field
- Significant experience in preclinical pharmacology within biotech or pharmaceutical settings
- Experience in choosing appropriate animal models
- Deep expertise in PK/PD modeling, with strong grounding in chemical kinetics and quantitative biology
- Proven experience designing studies to evaluate drug combinations and synergy, including application of factorial experimental design Demonstrated experience designing and interpreting in vivo pharmacology studies
- Experience in advancing preclinical candidates through IND-enabling studies and contributing meaningfully to IND submissions
- Strong statistical and data analysis skills
- Experience in metabolic diseases, particularly obesity and/or diabetes, strongly preferred
$180,000 - $230,000 a year
Final compensation will be based on a candidate’s qualifications, experience, and geographic location. Employees are also eligible for performance bonuses, equity participation and comprehensive health benefits.
\nWe believe in building balanced teams. We are an equal opportunity employer. We do not discriminate in regard to race, color, religion, national origin, age, sex, sexual orientation, gender identity, marital status, ancestry, physical or mental disability, veteran status, or any other legally protected characteristics.
Salary : $180,000 - $230,000