Senior Scientist, Translational PKPD Modeling & DMPK (Oncology)

Are you an authority in Oncology with a passion for PKPD modeling and DMPK science applied to Cancer biology? Do you want to make a real impact on patients' lives by turning scientific ideas into life-changing medicines? If so, AstraZeneca could be your next career destination! We are thrilled to offer an exciting opportunity for a Senior Scientist who is enthusiastic about PKPD modeling and DMPK science, particularly in the realm of Cancer biology. Ideally, you will have experience working with biologics drug projects and be ready to join our dynamic team. The Oncology DMPK department plays a pivotal role in advancing cancer treatment by providing expertise in drug metabolism, pharmacokinetics, and translational PKPD modeling to support a diverse oncology portfolio. With an ambition to become world leaders in oncology, the department strives to drive innovation through an extensive pipeline of innovative indications and targets, emphasizing launch excellence, commercial effectiveness, and maximized product lifecycles. As a Senior Scientist, individuals contribute by applying advanced PKPD modeling and simulation to deepen understanding of cancer biology and enhance drug discovery efforts. This position is responsible for providing specialist input on PK/PD/Efficacy in pre-clinical models, using these insights to iteratively define optimal dose and schedule strategies for therapeutic interventions. The role is central to advising treatment decisions across various patient populations, whether as monotherapy or in combination regimens. Accountabilities Represent Oncology DMPK, providing scientific leadership in cross-functional and external collaborations. Develop and apply PKPD models to explore the effects of target and pathway modulation, defining candidate drug target profiles. Predict human dose and regimen, contributing to exposure and pharmacodynamic biomarker-based decision-making for early clinical trials. Drive learning through back-translation of clinical exposure and pharmacodynamic data, offering strategic options for future clinical testing. Lead and participate in strategic scientific initiatives, continuous improvement projects, and external collaborations with academic or pre-competitive groups. Mentor students and postdoctoral fellows, contributing to the next generation of scientific talent. Present findings through publications, patents, and lectures, enhancing the visibility of AstraZeneca’s translational research. Essential Skills/Experience Ph.D. in Modeling & Simulation, systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, pharmaceutical sciences, or applied mathematics. 0 - 3 years of relevant industry experience in Modeling & Simulation, in preclinical/translational setting with a focus on biologics. Experience in a project-facing role within pharmaceutical R&D. Strong understanding of DMPK and pharmacology in drug discovery, with a track record of delivering results in a fast-paced environment. Proficiency with tools such as WinNonLin/Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, and SimCYP. Excellent interpersonal, communication, and leadership skills, with a passion for collaborative problem-solving. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. AstraZeneca offers an environment where courage, curiosity, and collaboration thrive. We are committed to pioneering new frontiers in Oncology with the ambition to eliminate cancer as a cause of death. Our innovative pipeline is backed by investment aimed at delivering breakthroughs through cutting-edge science and technology. With a diverse community internally and extensive collaborations externally, we expedite research in some of the hardest-to-treat cancers. Here, you can build a meaningful career while contributing to improving the lives of millions affected by cancer. Ready to make a difference? Apply now and join us on this exciting journey! Date Posted 25-Nov-2025 Closing Date Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.