Associate Principal Scientist, Immunology Cell Therapy Discovery

AstraZeneca, a global leader in biopharmaceuticals, is committed to discovering and delivering innovative therapies that transform patient outcomes. We are seeking a dedicated, hands-on Associate Principal Scientist to join our Immunology Cell Therapy Discovery team. The role centers on delivering scientific expertise for cell therapy discovery initiatives, underpinned by an in-depth understanding of immunological disease biology (e.g. multiple sclerosis) and/or expertise in CAR-T engineering (e.g., logic-gating) discovery. Accountabilities Expert Knowledge: Cultivate and maintain a comprehensive understanding of the immunology disease landscape, or viral vector design and genetic engineering, remaining abreast of the latest advancements and trends in the field. Collaborative Innovation: Work collaboratively with cross-functional teams to propel discovery efforts focused on immunological diseases, with the aim of enhancing AstraZeneca's portfolio. Stakeholder Engagement: Facilitate collaboration with key stakeholders both internally and externally to align cell therapy strategies with broader R&D objectives and goals. Regulatory Compliance: Ensure adherence to all relevant laws, regulations, and company policies related to the development and delivery of medicines. Research Assay and Research Process Development: Lead the development of in vitro assays and cell therapy research process to assess and validate novel therapeutic strategies and approaches. Essential Skills/Experience Advanced Degree: Masters with 5 years of relevant experience or PhD with 3 years of relevant experience in Immunology, Molecular or Cell Biology, Bioengineering, or a related field preferred Technical Expertise: Demonstrated proficiency in logic-gating (AND, NOT, IF/THEN gates), CAR configuration optimization, lentiviral, retroviral, or AAV vector design and engineering, CRISPR and other genetic engineering technologies, non-viral gene delivery technology, and in vitro/in vivo assays, and cell therapy research process development. Scientific Expertise: Deep understanding of disease biology and clinical landscape of immunological diseases (e.g. MS, RA, IBD) with a focus on cellular therapies. Collaborative Skills: Excellent collaboration and communication capabilities, adept at working effectively across various functional teams and organizational levels. Regulatory Insight: Comprehensive understanding of regulatory landscapes pertaining to cell therapy and genetic engineering. Negotiation and Influence: Proven track record to negotiate and influence effectively with senior management and industry partners. Desirable Skills/Experience Industry Network: Established connections within the cell therapy, genetic engineering, and immunology sectors. Publication Track Record: Strong history of peer-reviewed publications in immunological diseases and/or cell therapy engineering. At AstraZeneca, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. With one of the broadest and deepest Immunology pipelines in the industry, there are many opportunities to work with new and novel drugs. Our collaborative environment empowers us to take smart risks, challenge the norm, and learn from failures. We are united in our vision to eliminate cancer as a cause of death, making bold moves that truly improve patient outcomes. Join us in our mission to make a meaningful difference for patients around the world! The annual base pay for this position ranges from $134,892.80 - $202,339.20. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Date Posted 21-Nov-2025 Closing Date 12-Dec-2025 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.

Salary : $134,893 - $202,339