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Scientist, Protein Sciences

Memphis, TN | Other
17 Days Ago

Job Description

About Meridian

Meridian Bioscience is a fully integrated life science company that develops, manufactures, markets and distributes a broad range of innovative diagnostic products. We are dedicated to developing and delivering better solutions that give answers with speed, accuracy and simplicity that are redefining the possibilities of life from discovery to diagnosis. We are looking for talented and passionate individuals that help drive our vision. Our innovative culture will allow interested candidates to discover and create, through collaboration, cutting edge solutions to tough problems.

Job Summary

 The Scientist, Protein Sciences position will provide hands-on technical guidance within our Technical Operations and Development department to drive the improvement and growth of our immunological reagent offerings including recombinant proteins, native/viral antigens, monoclonal antibodies, polyclonal antibodies, blockers, and custom manufacturing. This position is responsible for leading the optimization and scale up of processes, troubleshooting manufacturing issues, improving product quality, and reducing manufacturing costs. The candidate will be responsible for conducting research and manufacturing related to vector development, fermentation, protein expression, protein purification, protein characterization, and assay development. The position will be required to work independently at the bench as well as effectively collaborate through communication of scientific findings to internal and external groups. The job function requires sound scientific judgment and innovation using advanced practices and procedures to achieve solutions.

 

Relationships:

  • Key Stakeholders
    • This position will collaborate with Technical Operations and Development to design experiments, execute experiments, and analyze generated data for assigned projects. The position will collaborate with various groups including quality and operations to complete both development projects and assigned custom manufacturing.
    • This position will interact with both internal and external contacts. This position will present scientific findings to the appropriate managerial teams. This position will be responsible to communicating with contract manufacturing clients regarding progress and technical issues.
  • Line Management
    • This position reports to the Manager, Technical Operations and Development.
    • This position can be an independent contributor or manage Senior Research Associates and Research Associates as assigned.
    • The direct reports for this position, if applicable, will be individual contributors.

 

Key Duties

  • Collaborate within multidisciplinary development and operational teams to improve and optimize products and processes, scale up processes, and manufacture custom products.
  • Design, clone, and optimize constructs that will be used to express proteins in Escherichia coli, Saccharomyces cerevisiae, and Pichia pastoris for commercial manufacturing.
  • Optimize and scale-up protein expression through research to understand fermentation parameters and media optimization.
  • Characterize microbial cell lines and microbial cell banking including growth, expression, and stability.
  • Develop assays that characterize protein expression and protein quality early in the production workflow.
  • Develop, execute, and scale up protein purification processes for recombinant proteins, monoclonal antibodies, and polyclonal antibodies. Unit operations include, but are not limited to, preparative centrifugation, depth filtration, tangential flow filtration, chromatographic methods (ion exchange, size exclusion, affinity, etc.), and product formulation.
  • Develop and perform various bio-analytical methods for process monitoring and product characterization. The methods include, but are not limited to, SDS-PAGE, Western Blot, ELISA, spectroscopic methods, HPLC methods.
  • Document and manage experimental methods and results within laboratory notebooks or manufacturing documentation. Prepare routine technical progress reports to be shared at internal and external meetings.
  • Help identify new technologies for protein and virus bioprocessing and characterization.
  • Lead technical transfer of developed procedures to production and/or quality personnel. Includes development of batch records, design of transfer plan, and execution of transfer plan including boots on the ground training.
  • Author batch records and SOPs for transferred/developed processes in compliance with current ISO13485 regulations and company SOPs.
  • Assist reviewing potential custom manufacturing projects, summarizing scope of work, and providing estimated costs required to complete scope of work.
  • Work effectively in a collaborative environment, communicate scientific findings freely, and instruct/ train personnel as required.
  • Perform routine laboratory maintenance and management including ordering of materials, cleaning and maintenance of laboratory equipment, etc.
  • Other tasks as assigned.

Qualifications

Knowledge, Skills and Abilities:

  • Extensive hands on experience with cloning, protein expression, and fermentation in microbial systems required. Specific experience with Saccharomyces cerevisiae and Pichia pastoris
  • Demonstrated ability to purify and characterize proteins through projects or publication record. A knowledge of AKTA FPLC systems and Unicorn software preferred.
  • Working knowledge of bioprocessing including process scale up preferred.
  • Demonstrated ability to design, document, and execute experiments. Must be able to accurately analyse and interpret generated results.
  • Open to learn and develop new techniques to support the development and improvement of immunological IVD reagents.
  • Well-organized, able to manage multiple projects, calm under pressure.
  • Proficient in technical writing, concise and accurate oral and written reporting of technical data.

Education and Experience:

  • A Bachelors, Masters, or Ph.D. from an accredited institution in a relevant scientific discipline such as Biochemistry, Molecular Biology, Protein Chemistry, etc. is required.
  • Required is 8 years of relevant research or industrial experience with a bachelors or Masters, or 0-2 years with a Ph.D.
  • A proven scientific track record with research related to protein structure, protein function, or protein manufacturing required.

 

Requirements:

  • Travel
    • Travel is minimal. Travel between business units, travel to scientific meetings, or travel for commercial meetings may be required.
  • Physical
    • Primary work requirements include working in a laboratory setting.
    • Must be able to perform repetitive movements including pipetting and typing.
    • Ability to concentrate, analyze, and solve complex issue throughout the day.
  • Other
    • May be required to work outside of normal business hours including evenings and/or weekends to support business needs.

We are proud to be an EEO/AA employer Minority/Female/Disability/Veteran. We maintain a drug-free workplace and perform pre-employment substance abuse testing.

Skills for Scientist, Protein Sciences

The job skills required for Scientist, Protein Sciences include Chemistry, Molecular Biology, Biochemistry, Troubleshooting, SOP,and Life Science etc. Having related job skills and expertise will give you an advantage when applying to be a Scientist, Protein Sciences. That makes you unique and can impact how much salary you can get paid. Below are job openings related to skills required by Scientist, Protein Sciences. Select any job title you are interested in and start to search job requirements.

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Career Path for Scientist, Protein Sciences

The following is the career advancement route for Scientist, Protein Sciences positions, which can be used as a reference in future career path planning. As a Scientist, Protein Sciences, it can be promoted into senior positions as a Clinical Research Manager that are expected to handle more key tasks, people in this role will get a higher salary paid than an ordinary Scientist, Protein Sciences. You can explore the career advancement for a Scientist, Protein Sciences below and select your interested title to get hiring information.